Focal FMRI Signal Enhancement with Implantable Inductively Coupled Detectors

Overview

Journal Neuroimage

Specialty Radiology

Date 2021 Dec 13

PMID 34896291

Citations 4

Authors

Yi Chen

Qi Wang

Sangcheon Choi

Hang Zeng

Kengo Takahashi

Chunqi Qian

Xin Yu

Affiliations

Soon will be listed here.

Abstract

Despite extensive efforts to increase the signal-to-noise ratio (SNR) of fMRI images for brain-wide mapping, technical advances of focal brain signal enhancement are lacking, in particular, for animal brain imaging. Emerging studies have combined fMRI with fiber optic-based optogenetics to decipher circuit-specific neuromodulation from meso to macroscales. High-resolution fMRI is needed to integrate hemodynamic responses into cross-scale functional dynamics, but the SNR remains a limiting factor given the complex implantation setup of animal brains. Here, we developed a multimodal fMRI imaging platform with an implanted inductive coil detector. This detector boosts the tSNR of MRI images, showing a 2-3-fold sensitivity gain over conventional coil configuration. In contrast to the cryoprobe or array coils with limited spaces for implanted brain interface, this setup offers a unique advantage to study brain circuit connectivity with optogenetic stimulation and can be further extended to other multimodal fMRI mapping schemes.

Citing Articles

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Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI.

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