The Current Status and Trend of the Functional Magnetic Resonance Combined with Stimulation in Animals

Overview

Journal Front Neurosci

Date 2022 Oct 10

PMID 36213733

Authors

Jiayang Huang

Yusi Zhang

Qi Zhang

Linxuan Wei

Xiwen Zhang

Caiping Jin

Junchao Yang

Zuanfang Li

Shengxiang Liang

Affiliations

Soon will be listed here.

Abstract

As a non-radiative, non-invasive imaging technique, functional magnetic resonance imaging (fMRI) has excellent effects on studying the activation of blood oxygen levels and functional connectivity of the brain in human and animal models. Compared with resting-state fMRI, fMRI combined with stimulation could be used to assess the activation of specific brain regions and the connectivity of specific pathways and achieve better signal capture with a clear purpose and more significant results. Various fMRI methods and specific stimulation paradigms have been proposed to investigate brain activation in a specific state, such as electrical, mechanical, visual, olfactory, and direct brain stimulation. In this review, the studies on animal brain activation using fMRI combined with different stimulation methods were retrieved. The instruments, experimental parameters, anesthesia, and animal models in different stimulation conditions were summarized. The findings would provide a reference for studies on estimating specific brain activation using fMRI combined with stimulation.

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