Physical Therapy Exerts Sub-additive and Suppressive Effects on Intracerebral Neural Stem Cell Implantation in a Rat Model of Stroke

Overview

Journal J Cereb Blood Flow Metab

Publisher Sage Publications

Specialties Cardiology & Vascular Diseases
Endocrinology
Neurology

Date 2021 Nov 26

PMID 34826373

Citations 5

Authors

Harmanvir Ghuman

Nikhita Perry

Lauren Grice

Madeline Gerwig

Jeffrey Moorhead Jr

Franziska Nitzsche

Alexander John Poplawsky

Fabrisia Ambrosio

Michel Modo

Affiliations

Soon will be listed here.

Abstract

Intracerebral cell therapy (CT) is emerging as a new therapeutic paradigm for stroke. However, the impact of physical therapy (PT) on implanted cells and their ability to promote recovery remains poorly understood. To address this translational issue, a clinical-grade neural stem cell (NSC) line was implanted into peri-infarct tissue using MRI-defined injection sites, two weeks after stroke. PT in the form of aerobic exercise (AE) was administered 5 × per week post-implantation using a paradigm commonly applied in patients with stroke. A combined AE and CT exerted sub-additive therapeutic effects on sensory neglect, whereas AE suppressed CT effects on motor integration and grip strength. Behavioral testing emerged as a potentially major component for task integration. It is expected that this study will guide and inform the incorporation of PT in the design of clinical trials evaluating intraparenchymal NSCs implantation for stroke.

Citing Articles

Advances in clinical translation of stem cell-based therapy in neurological diseases.

Wang Y, Cao Y, Xie W, Guo Y, Cai J, Huang T J Cereb Blood Flow Metab. 2025; :271678X251317374.

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The Complementary Roles of Neurological and Musculoskeletal Physical Therapy and Regenerative Medicine: A Comprehensive Review.

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Emergence of task-related spatiotemporal population dynamics in transplanted neurons.

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