Spectral Domain Optical Coherence Tomography of Multi-MHz A-scan Rates at 1310 Nm Range and Real-time 4D-display Up to 41 Volumes/second

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2012 Dec 18

PMID 23243560

Citations 30

Authors

Dong-Hak Choi

Hideaki Hiro-Oka

Kimiya Shimizu

Kohji Ohbayashi

Affiliations

Soon will be listed here.

Abstract

An ultrafast frequency domain optical coherence tomography system was developed at A-scan rates between 2.5 and 10 MHz, a B-scan rate of 4 or 8 kHz, and volume-rates between 12 and 41 volumes/second. In the case of the worst duty ratio of 10%, the averaged A-scan rate was 1 MHz. Two optical demultiplexers at a center wavelength of 1310 nm were used for linear-k spectral dispersion and simultaneous differential signal detection at 320 wavelengths. The depth-range, sensitivity, sensitivity roll-off by 6 dB, and axial resolution were 4 mm, 97 dB, 6 mm, and 23 μm, respectively. Using FPGAs for FFT and a GPU for volume rendering, a real-time 4D display was demonstrated at a rate up to 41 volumes/second for an image size of 256 (axial) × 128 × 128 (lateral) voxels.

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References

Tao Y, Ehlers J, Toth C, Izatt J . Intraoperative spectral domain optical coherence tomography for vitreoretinal surgery. Opt Lett. 2010; 35(20):3315-7. PMC: 3123722. DOI: 10.1364/OL.35.003315. View

Oh W, Vakoc B, Shishkov M, Tearney G, Bouma B . >400 kHz repetition rate wavelength-swept laser and application to high-speed optical frequency domain imaging. Opt Lett. 2010; 35(17):2919-21. PMC: 3003227. DOI: 10.1364/OL.35.002919. View

Huber R, Adler D, Fujimoto J . Buffered Fourier domain mode locking: Unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s. Opt Lett. 2006; 31(20):2975-7. DOI: 10.1364/ol.31.002975. View

Li J, Bloch P, Xu J, Sarunic M, Shannon L . Performance and scalability of Fourier domain optical coherence tomography acceleration using graphics processing units. Appl Opt. 2011; 50(13):1832-8. DOI: 10.1364/AO.50.001832. View

Adler D, Zhou C, Tsai T, Schmitt J, Huang Q, Mashimo H . Three-dimensional endomicroscopy of the human colon using optical coherence tomography. Opt Express. 2009; 17(2):784-96. PMC: 2886288. DOI: 10.1364/oe.17.000784. View

Vakoc B, Shishko M, Yun S, Oh W, Suter M, Desjardins A . Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video). Gastrointest Endosc. 2007; 65(6):898-905. PMC: 2705339. DOI: 10.1016/j.gie.2006.08.009. View

Klein T, Wieser W, Eigenwillig C, Biedermann B, Huber R . Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser. Opt Express. 2011; 19(4):3044-62. DOI: 10.1364/OE.19.003044. View

An L, Li P, Shen T, Wang R . High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A‑lines per second. Biomed Opt Express. 2011; 2(10):2770-83. PMC: 3191444. DOI: 10.1364/BOE.2.002770. View

Watanabe H, Rajagopalan U, Nakamichi Y, Igarashi K, Kadono H, Tanifuji M . Swept source optical coherence tomography as a tool for real time visualization and localization of electrodes used in electrophysiological studies of brain in vivo. Biomed Opt Express. 2011; 2(11):3129-34. PMC: 3207381. DOI: 10.1364/BOE.2.003129. View

10.

Geerling G, Muller M, Winter C, Hoerauf H, Oelckers S, Laqua H . Intraoperative 2-dimensional optical coherence tomography as a new tool for anterior segment surgery. Arch Ophthalmol. 2005; 123(2):253-7. DOI: 10.1001/archopht.123.2.253. View

11.

Jenkins M, ROTHENBERG F, Roy D, Nikolski V, Hu Z, Watanabe M . 4D embryonic cardiography using gated optical coherence tomography. Opt Express. 2009; 14(2):736-48. DOI: 10.1364/opex.14.000736. View

12.

Van der Jeught S, Bradu A, Podoleanu A . Real-time resampling in Fourier domain optical coherence tomography using a graphics processing unit. J Biomed Opt. 2010; 15(3):030511. DOI: 10.1117/1.3437078. View

13.

Bonin T, Franke G, Hagen-Eggert M, Koch P, Huttmann G . In vivo Fourier-domain full-field OCT of the human retina with 1.5 million A-lines/s. Opt Lett. 2010; 35(20):3432-4. DOI: 10.1364/OL.35.003432. View

14.

Liu G, Zhang J, Yu L, Xie T, Chen Z . Real-time polarization-sensitive optical coherence tomography data processing with parallel computing. Appl Opt. 2009; 48(32):6365-70. PMC: 2866633. DOI: 10.1364/AO.48.006365. View

15.

Choi D, Hiro-Oka H, Furukawa H, Yoshimura R, Nakanishi M, Shimizu K . Fourier domain optical coherence tomography using optical demultiplexers imaging at 60,000,000 lines/s. Opt Lett. 2008; 33(12):1318-20. DOI: 10.1364/ol.33.001318. View

16.

Just T, Lankenau E, Huttmann G, Pau H . Intra-operative application of optical coherence tomography with an operating microscope. J Laryngol Otol. 2009; 123(9):1027-30. DOI: 10.1017/S0022215109004770. View

17.

Ustun T, Iftimia N, Ferguson R, Hammer D . Real-time processing for Fourier domain optical coherence tomography using a field programmable gate array. Rev Sci Instrum. 2008; 79(11):114301. PMC: 2678783. DOI: 10.1063/1.3005996. View

18.

Gargesha M, Jenkins M, Wilson D, Rollins A . High temporal resolution OCT using image-based retrospective gating. Opt Express. 2009; 17(13):10786-99. PMC: 2748662. DOI: 10.1364/oe.17.010786. View

19.

Potsaid B, Baumann B, Huang D, Barry S, Cable A, Schuman J . Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second. Opt Express. 2010; 18(19):20029-48. PMC: 3136869. DOI: 10.1364/OE.18.020029. View

20.

Yang Y, Whiteman S, Gey van Pittius D, He Y, Wang R, Spiteri M . Use of optical coherence tomography in delineating airways microstructure: comparison of OCT images to histopathological sections. Phys Med Biol. 2004; 49(7):1247-55. DOI: 10.1088/0031-9155/49/7/012. View