Review of Optical Coherence Tomography in Oncology

Overview

Journal J Biomed Opt

Specialties Biomedical Engineering
Ophthalmology

Date 2017 Dec 24

PMID 29274145

Citations 53

Authors

Jianfeng Wang

Yang Xu

Stephen A Boppart

Affiliations

Soon will be listed here.

Abstract

The application of optical coherence tomography (OCT) in the field of oncology has been prospering over the past decade. OCT imaging has been used to image a broad spectrum of malignancies, including those arising in the breast, brain, bladder, the gastrointestinal, respiratory, and reproductive tracts, the skin, and oral cavity, among others. OCT imaging has initially been applied for guiding biopsies, for intraoperatively evaluating tumor margins and lymph nodes, and for the early detection of small lesions that would often not be visible on gross examination, tasks that align well with the clinical emphasis on early detection and intervention. Recently, OCT imaging has been explored for imaging tumor cells and their dynamics, and for the monitoring of tumor responses to treatments. This paper reviews the evolution of OCT technologies for the clinical application of OCT in surgical and noninvasive interventional oncology procedures and concludes with a discussion of the future directions for OCT technologies, with particular emphasis on their applications in oncology.

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References

Arruebo M, Vilaboa N, Saez-Gutierrez B, Lambea J, Tres A, Valladares M . Assessment of the evolution of cancer treatment therapies. Cancers (Basel). 2013; 3(3):3279-330. PMC: 3759197. DOI: 10.3390/cancers3033279. View

Yuan Z, Wang Z, Pan R, Liu J, Cohen H, Pan Y . High-resolution imaging diagnosis and staging of bladder cancer: comparison between optical coherence tomography and high-frequency ultrasound. J Biomed Opt. 2008; 13(5):054007. DOI: 10.1117/1.2978059. View

Zhou C, Tsai T, Adler D, Lee H, Cohen D, Mondelblatt A . Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells. Opt Lett. 2010; 35(5):700-2. PMC: 2890232. DOI: 10.1364/OL.35.000700. View

Liang J, Williams D, Miller D . Supernormal vision and high-resolution retinal imaging through adaptive optics. J Opt Soc Am A Opt Image Sci Vis. 1997; 14(11):2884-92. DOI: 10.1364/josaa.14.002884. View

Aguirre A, Chen Y, Bryan B, Mashimo H, Huang Q, Connolly J . Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy. J Biomed Opt. 2010; 15(1):016025. PMC: 2847935. DOI: 10.1117/1.3322704. View

Vakoc B, Shishko M, Yun S, Oh W, Suter M, Desjardins A . Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video). Gastrointest Endosc. 2007; 65(6):898-905. PMC: 2705339. DOI: 10.1016/j.gie.2006.08.009. View

McLaughlin S, Wright M, Morris K, Giron G, Sampson M, Brockway J . Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection: objective measurements. J Clin Oncol. 2008; 26(32):5213-9. PMC: 2652091. DOI: 10.1200/JCO.2008.16.3725. View

Leitgeb R, Villiger M, Bachmann A, Steinmann L, Lasser T . Extended focus depth for Fourier domain optical coherence microscopy. Opt Lett. 2006; 31(16):2450-2. DOI: 10.1364/ol.31.002450. View

Gallwas J, Turk L, Stepp H, Mueller S, Ochsenkuehn R, Friese K . Optical coherence tomography for the diagnosis of cervical intraepithelial neoplasia. Lasers Surg Med. 2011; 43(3):206-12. DOI: 10.1002/lsm.21030. View

10.

Zysk A, Boppart S . Computational methods for analysis of human breast tumor tissue in optical coherence tomography images. J Biomed Opt. 2006; 11(5):054015. DOI: 10.1117/1.2358964. View

11.

Quirk B, McLaughlin R, Curatolo A, Kirk R, Noble P, Sampson D . In situ imaging of lung alveoli with an optical coherence tomography needle probe. J Biomed Opt. 2011; 16(3):036009. DOI: 10.1117/1.3556719. View

12.

Sivak Jr M, Kobayashi K, Izatt J, Rollins A, Chak A, Wong R . High-resolution endoscopic imaging of the GI tract using optical coherence tomography. Gastrointest Endosc. 2000; 51(4 Pt 1):474-9. DOI: 10.1016/s0016-5107(00)70450-0. View

13.

Mogensen M, Joergensen T, Nurnberg B, Morsy H, Thomsen J, Thrane L . Assessment of optical coherence tomography imaging in the diagnosis of non-melanoma skin cancer and benign lesions versus normal skin: observer-blinded evaluation by dermatologists and pathologists. Dermatol Surg. 2009; 35(6):965-72. DOI: 10.1111/j.1524-4725.2009.01164.x. View

14.

Erickson-Bhatt S, Nolan R, Shemonski N, Adie S, Putney J, Darga D . Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery. Cancer Res. 2015; 75(18):3706-12. PMC: 4749141. DOI: 10.1158/0008-5472.CAN-15-0464. View

15.

Hermes B, Spoler F, Naami A, Bornemann J, Forst M, Grosse J . Visualization of the basement membrane zone of the bladder by optical coherence tomography: feasibility of noninvasive evaluation of tumor invasion. Urology. 2008; 72(3):677-81. DOI: 10.1016/j.urology.2008.02.062. View

16.

Evans C, Rizvi I, Hasan T, de Boer J . In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging. Opt Express. 2009; 17(11):8892-906. PMC: 2836890. DOI: 10.1364/oe.17.008892. View

17.

Burns J, Kim K, deBoer J, Anderson R, Zeitels S . Polarization-sensitive optical coherence tomography imaging of benign and malignant laryngeal lesions: an in vivo study. Otolaryngol Head Neck Surg. 2011; 145(1):91-9. DOI: 10.1177/0194599811403078. View

18.

Vakoc B, Lanning R, Tyrrell J, Padera T, Bartlett L, Stylianopoulos T . Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nat Med. 2009; 15(10):1219-23. PMC: 2759417. DOI: 10.1038/nm.1971. View

19.

Kennedy B, McLaughlin R, Kennedy K, Chin L, Curatolo A, Tien A . Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure. Biomed Opt Express. 2014; 5(7):2113-24. PMC: 4102352. DOI: 10.1364/BOE.5.002113. View

20.

Boppart S, Luo W, Marks D, Singletary K . Optical coherence tomography: feasibility for basic research and image-guided surgery of breast cancer. Breast Cancer Res Treat. 2004; 84(2):85-97. DOI: 10.1023/B:BREA.0000018401.13609.54. View