Enabling Stem Cell Therapies Through Synthetic Stem Cell-niche Engineering

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2010 Jan 7

PMID 20051637

Citations 62

Authors

Raheem Peerani

Peter W Zandstra

Affiliations

Soon will be listed here.

Abstract

Enabling stem cell-targeted therapies requires an understanding of how to create local microenvironments (niches) that stimulate endogenous stem cells or serve as a platform to receive and guide the integration of transplanted stem cells and their derivatives. In vivo, the stem cell niche is a complex and dynamic unit. Although components of the in vivo niche continue to be described for many stem cell systems, how these components interact to modulate stem cell fate is only beginning to be understood. Using the HSC niche as a model, we discuss here microscale engineering strategies capable of systematically examining and reconstructing individual niche components. Synthetic stem cell-niche engineering may form a new foundation for regenerative therapies.

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