Constructing a Cell Microenvironment with Biomaterial Scaffolds for Stem Cell Therapy

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2021 Nov 23

PMID 34809719

Citations 26

Authors

Xiaotong Zhao

Qiong Li

Zhikun Guo

Zongjin Li

Affiliations

Soon will be listed here.

Abstract

Stem cell therapy is widely recognized as a promising strategy for exerting therapeutic effects after injury in degenerative diseases. However, limitations such as low cell retention and survival rates after transplantation exist in clinical applications. In recent years, emerging biomaterials that provide a supportable cellular microenvironment for transplanted cells have optimized the therapeutic efficacy of stem cells in injured tissues or organs. Advances in the engineered microenvironment are revolutionizing our understanding of stem cell-based therapies by co-transplanting with synthetic and tissue-derived biomaterials, which offer a scaffold for stem cells and propose an unprecedented opportunity to further employ significant influences in tissue repair and regeneration.

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