Peter W Zandstra
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Explore the profile of Peter W Zandstra including associated specialties, affiliations and a list of published articles.
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149
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7010
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Recent Articles
1.
Johnstone C, Love K, Kabaria S, Jones R, Jones R, Blanch-Asensio A, et al.
bioRxiv
. 2025 Jan;
PMID: 39868195
Gene syntax-the order and arrangement of genes and their regulatory elements-shapes the dynamic coordination of both natural and synthetic gene circuits. Transcription at one locus profoundly impacts the transcription of...
2.
Michaels Y, Major M, Bonham-Carter B, Zhang J, Heydari T, Edgar J, et al.
Cell Syst
. 2024 Nov;
15(12):1245-1263.e10.
PMID: 39615483
T cells develop from hematopoietic progenitors in the thymus and protect against pathogens and cancer. However, the emergence of human T cell-competent blood progenitors and their subsequent specification to the...
3.
Stankiewicz L, Salim K, Flaschner E, Wang Y, Edgar J, Durland L, et al.
Dev Cell
. 2024 Oct;
60(1):152-169.e8.
PMID: 39383865
Within the thymus, regulation of the cellular crosstalk directing T cell development depends on spatial interactions within specialized niches. To create a spatially defined map of tissue niches guiding human ...
4.
Leung J, Primbetova A, Strong C, Hay B, Hsu H, Hagner A, et al.
J Thromb Haemost
. 2024 Sep;
23(1):306-313.
PMID: 39341369
Background: Platelets are an essential component of hemorrhage control and management, and engineering platelets to express therapeutic proteins could expand their use as a cell therapy. Genetically engineered platelets can...
5.
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification
Dattani A, Corujo-Simon E, Radley A, Heydari T, Taheriabkenar Y, Carlisle F, et al.
Cell Stem Cell
. 2024 Jun;
31(7):1058-1071.e5.
PMID: 38823388
The hypoblast is an essential extraembryonic tissue set aside within the inner cell mass in the blastocyst. Research with human embryos is challenging. Thus, stem cell models that reproduce hypoblast...
6.
Stankiewicz L, Rossi F, Zandstra P
Cell Stem Cell
. 2024 Apr;
31(5):597-616.
PMID: 38593798
Advances in modern medicine have enabled a rapid increase in lifespan and, consequently, have highlighted the immune system as a key driver of age-related disease. Immune regeneration therapies present exciting...
7.
Michaels Y, Durland L, Zandstra P
GEN Biotechnol
. 2023 Nov;
2(2):106-119.
PMID: 37928777
Engineered T cells are at the leading edge of clinical cell therapy. T cell therapies have had a remarkable impact on patient care for a subset of hematological malignancies. This...
8.
Kirouac D, Zmurchok C, Deyati A, Sicherman J, Bond C, Zandstra P
Nat Biotechnol
. 2023 May;
41(11):1655.
PMID: 37188917
No abstract available.
9.
Stankiewicz L, Salim K, Flaschner E, Wang Y, Edgar J, Lin B, et al.
bioRxiv
. 2023 Apr;
PMID: 37090676
Within the thymus, regulation of the cellular cross-talk directing T cell development is dependent on spatial interactions within specialized niches. To create a holistic, spatially defined map of tissue niches...
10.
Kirouac D, Zmurchok C, Deyati A, Sicherman J, Bond C, Zandstra P
Nat Biotechnol
. 2023 Feb;
41(11):1606-1617.
PMID: 36849828
Chimeric antigen receptor T cell (CAR-T) expansion and persistence vary widely among patients and predict both efficacy and toxicity. However, the mechanisms underlying clinical outcomes and patient variability are poorly...