Cardiac Cell Repair Therapy: a Clinical Perspective

Overview

Journal Mayo Clin Proc

Specialty General Medicine

Date 2009 Oct 3

PMID 19797777

Citations 52

Authors

Bernard J Gersh

Robert D Simari

Atta Behfar

Carmen M Terzic

Andre Terzic

Affiliations

Soon will be listed here.

Abstract

From bone marrow transplants 5 decades ago to the most recent stem cell-derived organ transplants, regenerative medicine is increasingly recognized as an emerging core component of modern practice. In cardiovascular medicine, innovation in stem cell biology has created curative solutions for the treatment of both ischemic and nonischemic cardiomyopathy. Multiple cell-based platforms have been developed, harnessing the regenerative potential of various natural and bioengineered sources. Clinical experience from the first 1000 patients (approximately) who have received stem cell therapy worldwide indicates a favorable safety profile with modest improvement in cardiac function and structural remodeling in the setting of acute myocardial infarction or chronic heart failure. Further investigation is required before early adoption and is ongoing. Broader application in practice will require continuous scientific advances to match each patient with the most effective reparative phenotype, while ensuring optimal cell delivery, dosing, and timing of intervention. An interdisciplinary effort across the scientific and clinical community within academia, biotechnology, and government will drive the successful realization of this next generation of therapeutic agents for the "broken" heart.

Citing Articles

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model.

Olthoff M, Franchi F, Peterson K, Paulmurugan R, Rodriguez-Porcel M J Vis Exp. 2020; (163).

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Selection of human induced pluripotent stem cells lines optimization of cardiomyocytes differentiation in an integrated suspension microcarrier bioreactor.

Laco F, Lam A, Woo T, Tong G, Ho V, Soong P Stem Cell Res Ther. 2020; 11(1):118.

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Changing Metabolism in Differentiating Cardiac Progenitor Cells-Can Stem Cells Become Metabolically Flexible Cardiomyocytes?.

Malandraki-Miller S, Lopez C, Al-Siddiqi H, Carr C Front Cardiovasc Med. 2018; 5:119.

PMID: 30283788 PMC: 6157401. DOI: 10.3389/fcvm.2018.00119.

Impaired redox environment modulates cardiogenic and ion-channel gene expression in cardiac-resident and non-resident mesenchymal stem cells.

Subramani B, Subbannagounder S, Ramanathanpullai C, Palanivel S, Ramasamy R Exp Biol Med (Maywood). 2017; 242(6):645-656.

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Progenitor Hematopoietic Cells Implantation Improves Functional Capacity of End Stage Coronary Artery Disease Patients with Advanced Heart Failure.

Yuniadi Y, Kusnadi Y, Sandhow L, Erika R, Hanafy D, Sardjono C Cardiol Res Pract. 2016; 2016:3942605.

PMID: 27148465 PMC: 4842367. DOI: 10.1155/2016/3942605.

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