Yoh-Hei Takahashi
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Explore the profile of Yoh-Hei Takahashi including associated specialties, affiliations and a list of published articles.
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23
Citations
1545
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Recent Articles
1.
Aoi Y, Takahashi Y, Shah A, Iwanaszko M, Rendleman E, Khan N, et al.
Mol Cell
. 2021 Sep;
81(21):4413-4424.e5.
PMID: 34480849
Based on in vitro studies, it has been demonstrated that the DSIF complex, composed of SPT4 and SPT5, regulates the elongation stage of transcription catalyzed by RNA polymerase II (RNA...
2.
Zhou Y, Han C, Wang E, Lorch A, Serafin V, Cho B, et al.
Cancer Discov
. 2020 May;
10(9):1388-1409.
PMID: 32444465
Splicing alterations are common in diseases such as cancer, where mutations in splicing factor genes are frequently responsible for aberrant splicing. Here we present an alternative mechanism for splicing regulation...
3.
Yang Y, Joshi M, Takahashi Y, Ning Z, Qu Q, Brunzelle J, et al.
Nucleic Acids Res
. 2019 Nov;
48(1):421-431.
PMID: 31724694
COMPlex ASsociating with SET1 (COMPASS) is a histone H3 Lys-4 methyltransferase that typically marks the promoter region of actively transcribed genes. COMPASS is a multi-subunit complex in which the catalytic...
4.
Haddad J, Yang Y, Takahashi Y, Joshi M, Chaudhary N, Woodfin A, et al.
Structure
. 2018 Oct;
26(12):1594-1603.e4.
PMID: 30270175
Dpy-30 is a regulatory subunit controlling the histone methyltransferase activity of the KMT2 enzymes in vivo. Paradoxically, in vitro methyltransferase assays revealed that Dpy-30 only modestly participates in the positive...
5.
Jin Q, Martinez C, Arcipowski K, Zhu Y, Gutierrez-Diaz B, Wang K, et al.
Clin Cancer Res
. 2018 Sep;
25(1):222-239.
PMID: 30224337
Purpose: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease, affecting children and adults. Chemotherapy treatments show high response rates but have debilitating effects and carry risk of relapse. Previous...
6.
Qu Q, Takahashi Y, Yang Y, Hu H, Zhang Y, Brunzelle J, et al.
Cell
. 2018 Aug;
174(5):1117-1126.e12.
PMID: 30100186
The methylation of histone 3 lysine 4 (H3K4) is carried out by an evolutionarily conserved family of methyltransferases referred to as complex of proteins associated with Set1 (COMPASS). The activity...
7.
Wang L, Zhao Z, Ozark P, Fantini D, Marshall S, Rendleman E, et al.
Nat Med
. 2018 May;
24(6):758-769.
PMID: 29785026
The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene enhancers. KMT2C (hereafter referred to as...
8.
Rickels R, Herz H, Sze C, Cao K, Morgan M, Collings C, et al.
Nat Genet
. 2017 Oct;
49(11):1647-1653.
PMID: 28967912
Histone H3 lysine 4 monomethylation (H3K4me1) is an evolutionarily conserved feature of enhancer chromatin catalyzed by the COMPASS-like methyltransferase family, which includes Trr in Drosophila melanogaster and MLL3 (encoded by...
9.
Piunti A, Hashizume R, Morgan M, Bartom E, Horbinski C, Marshall S, et al.
Nat Med
. 2017 Mar;
23(4):493-500.
PMID: 28263307
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brainstem tumor characterized by rapid and uniform patient demise. A heterozygous point mutation of histone H3 occurs in more than...
10.
DUrso A, Takahashi Y, Xiong B, Marone J, Coukos R, Randise-Hinchliff C, et al.
Elife
. 2016 Jun;
5.
PMID: 27336723
In yeast and humans, previous experiences can lead to epigenetic transcriptional memory: repressed genes that exhibit mitotically heritable changes in chromatin structure and promoter recruitment of poised RNA polymerase II...