Georgios Skiniotis
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Explore the profile of Georgios Skiniotis including associated specialties, affiliations and a list of published articles.
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125
Citations
8286
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Recent Articles
1.
Yang X, He F, Porter D, Garbett K, Meyers R, Reynolds D, et al.
bioRxiv
. 2025 Mar;
PMID: 40060693
Homeostasis relies on signaling networks controlled by cell membrane receptors. Although G-protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors, their specific roles in the epidermis are not fully...
2.
Clayton J, Shi L, Robertson M, Skiniotis G, Michaelides M, Stavitskaya L, et al.
bioRxiv
. 2025 Feb;
PMID: 39990498
Nitazenes are a class of novel synthetic opioids with exceptionally high potency. Currently, an experimental structure of OR-opioid receptor (OR) in complex with a nitazene is lacking. Here we used...
3.
Liu F, Wu C, Tu C, Glenn I, Meyerowitz J, Kaplan A, et al.
Science
. 2024 Sep;
385(6715):eado1868.
PMID: 39298584
Positive allosteric modulator (PAM) drugs enhance the activation of the calcium-sensing receptor (CaSR) and suppress parathyroid hormone (PTH) secretion. Unfortunately, these hyperparathyroidism-treating drugs can induce hypocalcemia and arrhythmias. Seeking improved...
4.
Batebi H, Perez-Hernandez G, Rahman S, Lan B, Kamprad A, Shi M, et al.
Nat Struct Mol Biol
. 2024 Jun;
31(11):1692-1701.
PMID: 38867113
G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by promoting guanine nucleotide exchange. Here, we investigate the coupling of G proteins with GPCRs and describe the events that ultimately lead to...
5.
Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain M, et al.
Science
. 2024 May;
384(6702):eadn6354.
PMID: 38753765
AlphaFold2 (AF2) models have had wide impact but mixed success in retrospective ligand recognition. We prospectively docked large libraries against unrefined AF2 models of the σ and serotonin 2A (5-HT2A)...
6.
Papasergi-Scott M, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven A, et al.
Nature
. 2024 Mar;
629(8014):1182-1191.
PMID: 38480881
G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by stimulating guanine nucleotide exchange in the Gα subunit. To visualize this mechanism, we developed a time-resolved cryo-EM approach that examines the progression...
7.
He F, Wu C, Gao Y, Rahman S, Zaoralova M, Papasergi-Scott M, et al.
Nature
. 2024 Feb;
626(8001):1141-1148.
PMID: 38326620
The calcium-sensing receptor (CaSR) is a family C G-protein-coupled receptor (GPCR) that has a central role in regulating systemic calcium homeostasis. Here we use cryo-electron microscopy and functional assays to...
8.
Liu F, Wu C, Tu C, Glenn I, Meyerowitz J, Kaplan A, et al.
bioRxiv
. 2024 Jan;
PMID: 38234749
Drugs acting as positive allosteric modulators (PAMs) to enhance the activation of the calcium sensing receptor (CaSR) and to suppress parathyroid hormone (PTH) secretion can treat hyperparathyroidism but suffer from...
9.
Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain M, et al.
bioRxiv
. 2024 Jan;
PMID: 38187536
AlphaFold2 (AF2) and RosettaFold have greatly expanded the number of structures available for structure-based ligand discovery, even though retrospective studies have cast doubt on their direct usefulness for that goal....
10.
Vizurraga A, Robertson M, Yu M, Skiniotis G, Tall G
Mol Pharmacol
. 2023 Jun;
104(1):28-41.
PMID: 37290962
GPR56 is a widely expressed adhesion GPCR (AGPCR) that has pleotropic roles in brain development, platelet function, cancer, and more. Nearly all AGPCRs possess extracellular regions that bind protein ligands...