Yasumichi Hitoshi
Overview
Explore the profile of Yasumichi Hitoshi including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
767
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0
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Recent Articles
1.
Shaw S, Goff D, Boralsky L, Singh R, Sweeny D, Park G, et al.
J Med Chem
. 2023 Dec;
66(24):17086-17104.
PMID: 38079537
A set of focused analogues have been generated around a lead indirect adenosine monophosphate-activated kinase (AMPK) activator to improve the rat clearance of the molecule. Analogues were focused on inhibiting...
2.
Thi Viet Ha M, Hamana H, Shitaoka K, Hayee A, Kobayashi E, Yoshikawa T, et al.
Cancer Sci
. 2023 Mar;
114(6):2254-2264.
PMID: 36866942
The clinical success of T cell receptor (TCR) gene-transduced T (TCR-T) cell therapy is expected as one of the next-generation immunotherapies for cancer, in which the selection of TCRs with...
3.
Shaw S, Goff D, Carroll D, Singh R, Sweeny D, Park G, et al.
Bioorg Med Chem
. 2022 Aug;
71:116951.
PMID: 35973281
Using an in-cell AMPK activation assay, we have developed structure-activity relationships around a hit pyridine dicarboxamide 5 that resulted in 40 (R419). A particular focus was to retain the on-target...
4.
Yasui Y, Hitoshi Y, Kaneko S
Methods Mol Biol
. 2019 Aug;
2048:77-80.
PMID: 31396931
In order to differentiate T cells in vitro, co-culture systems with Notch ligand-expressing feeder cells have been in use for a long time. Here we describe a feeder-free culture condition...
5.
Yan Y, Zhou X, Novick S, Shaw S, Li Y, Brunzelle J, et al.
J Biol Chem
. 2018 Nov;
294(3):953-967.
PMID: 30478170
AMP-activated protein kinase (AMPK) is an attractive therapeutic target for managing metabolic diseases. A class of pharmacological activators, including Merck 991, binds the AMPK ADaM site, which forms the interaction...
6.
Ni H, Shirazi F, Baladandayuthapani V, Lin H, Kuiatse I, Wang H, et al.
Clin Cancer Res
. 2018 Aug;
24(24):6408-6420.
PMID: 30126942
Purpose: Waldenström's macroglobulinemia is an incurable lymphoproliferative disorder driven by an L265P mutation in the myeloid differentiation primary response gene 88 (), which activates downstream NF-κB signaling through the Myddosome....
7.
Mejia G, Asiedu M, Hitoshi Y, Dussor G, Price T
Pain Rep
. 2016 Sep;
1(1).
PMID: 27672681
There is a great need for new therapeutics for the treatment of pain. A possible avenue to development of such therapeutics is to interfere with signaling pathways engaged in peripheral...
8.
Marcinko K, Bujak A, Lally J, Ford R, Wong T, Smith B, et al.
Mol Metab
. 2015 Sep;
4(9):643-51.
PMID: 26413470
Objective: Skeletal muscle AMP-activated protein kinase (AMPK) is important for regulating glucose homeostasis, mitochondrial content and exercise capacity. R419 is a mitochondrial complex-I inhibitor that has recently been shown to...
9.
Tada S, Okuno T, Hitoshi Y, Yasui T, Honorat J, Takata K, et al.
J Neuroinflammation
. 2014 Oct;
11:179.
PMID: 25326688
Background: Accumulating evidence has shown that the inflammatory process participates in the pathogenesis of amyotrophic lateral sclerosis (ALS), suggesting a therapeutic potential of anti-inflammatory agents. Janus kinase 2 (JAK2), one...
10.
Jenkins Y, Sun T, Li Y, Markovtsov V, Uy G, Gross L, et al.
BMC Res Notes
. 2014 Sep;
7:674.
PMID: 25252968
Background: The novel small molecule R118 and the biguanide metformin, a first-line therapy for type 2 diabetes (T2D), both activate the critical cellular energy sensor 5'-AMP-activated protein kinase (AMPK) via...