Tian-Qiang Sun
Overview
Explore the profile of Tian-Qiang Sun including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
80
Followers
0
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Recent Articles
1.
Shaw S, Goff D, Boralsky L, Singh R, Sweeny D, Park G, et al.
J Med Chem
. 2023 Dec;
66(24):17086-17104.
PMID: 38079537
A set of focused analogues have been generated around a lead indirect adenosine monophosphate-activated kinase (AMPK) activator to improve the rat clearance of the molecule. Analogues were focused on inhibiting...
2.
Shaw S, Goff D, Carroll D, Singh R, Sweeny D, Park G, et al.
Bioorg Med Chem
. 2022 Aug;
71:116951.
PMID: 35973281
Using an in-cell AMPK activation assay, we have developed structure-activity relationships around a hit pyridine dicarboxamide 5 that resulted in 40 (R419). A particular focus was to retain the on-target...
3.
Valencia K, Erice O, Kostyrko K, Hausmann S, Guruceaga E, Tathireddy A, et al.
J Clin Invest
. 2019 Dec;
130(4):1879-1895.
PMID: 31874105
Few therapies are currently available for patients with KRAS-driven cancers, highlighting the need to identify new molecular targets that modulate central downstream effector pathways. Here we found that the microRNA...
4.
Jenkins Y, Sun T, Li Y, Markovtsov V, Uy G, Gross L, et al.
BMC Res Notes
. 2014 Sep;
7:674.
PMID: 25252968
Background: The novel small molecule R118 and the biguanide metformin, a first-line therapy for type 2 diabetes (T2D), both activate the critical cellular energy sensor 5'-AMP-activated protein kinase (AMPK) via...
5.
Baltgalvis K, White K, Li W, Claypool M, Lang W, Alcantara R, et al.
Am J Physiol Heart Circ Physiol
. 2014 Feb;
306(8):H1128-45.
PMID: 24561866
Intermittent claudication is a form of exercise intolerance characterized by muscle pain during walking in patients with peripheral artery disease (PAD). Endothelial cell and muscle dysfunction are thought to be...
6.
Jenkins Y, Sun T, Markovtsov V, Foretz M, Li W, Nguyen H, et al.
PLoS One
. 2013 Dec;
8(12):e81870.
PMID: 24339975
Modulation of mitochondrial function through inhibiting respiratory complex I activates a key sensor of cellular energy status, the 5'-AMP-activated protein kinase (AMPK). Activation of AMPK results in the mobilization of...
7.
Zhang J, Sun T
Vitam Horm
. 2009 Mar;
80:389-407.
PMID: 19251045
Insulin receptor substrate 2 (IRS-2) is a key molecule in insulin signaling pathway, serving as an adaptor protein to insulin receptor to activate downstream kinase cascades, including MAP kinase and...