Vadim Markovtsov
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Explore the profile of Vadim Markovtsov including associated specialties, affiliations and a list of published articles.
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19
Citations
506
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Recent Articles
1.
Lee M, Hammouda M, Miao W, Okafor A, Jin Y, Sun H, et al.
J Invest Dermatol
. 2024 May;
144(12):2742-2753.
PMID: 38796140
UBE2N, a Lys63 ubiquitin-conjugating enzyme, plays critical roles in embryogenesis and immune system development and function. However, its roles in adult epithelial tissue homeostasis and pathogenesis are unclear. We generated...
2.
Markovtsov V, Duncton M, Bagos A, Yi S, Braselmann S, Bhamidipati S, et al.
ACS Med Chem Lett
. 2023 Dec;
14(12):1700-1706.
PMID: 38116420
Dimethyl fumarate is approved for the treatment of multiple sclerosis but is also associated with off-target activation of the niacin receptor. By using a tetrazolone or triazolone bioisostere approach to...
3.
Lee M, Hammouda M, Miao W, Okafor A, Jin Y, Sun H, et al.
bioRxiv
. 2023 Dec;
PMID: 38105982
UBE2N, a Lys63-ubiquitin conjugating enzyme, plays critical roles in embryogenesis and immune system development and function. However, its roles in adult epithelial tissue homeostasis and pathogenesis are unclear. We generated...
4.
Shaw S, Goff D, Boralsky L, Singh R, Sweeny D, Park G, et al.
J Med Chem
. 2023 Dec;
66(24):17086-17104.
PMID: 38079537
A set of focused analogues have been generated around a lead indirect adenosine monophosphate-activated kinase (AMPK) activator to improve the rat clearance of the molecule. Analogues were focused on inhibiting...
5.
Cooper N, Ghanima W, Hill Q, Nicolson P, Markovtsov V, Kessler C
Platelets
. 2022 Nov;
34(1):2131751.
PMID: 36331249
Spleen tyrosine kinase (SYK) is an important regulatory molecule of signal transduction pathways involved in the pathogenesis of autoimmune diseases such as immune thrombocytopenia (ITP), and the SYK-signaling pathway has...
6.
Shaw S, Goff D, Carroll D, Singh R, Sweeny D, Park G, et al.
Bioorg Med Chem
. 2022 Aug;
71:116951.
PMID: 35973281
Using an in-cell AMPK activation assay, we have developed structure-activity relationships around a hit pyridine dicarboxamide 5 that resulted in 40 (R419). A particular focus was to retain the on-target...
7.
Cooper N, Altomare I, Thomas M, Nicolson P, Watson S, Markovtsov V, et al.
Ther Adv Hematol
. 2021 May;
12:20406207211010875.
PMID: 33995988
Background: Patients with immune thrombocytopenia (ITP) are at risk of bleeding and, paradoxically, thromboembolic events (TEEs), irrespective of thrombocytopenia. The risk of thrombosis is increased by advanced age, obesity, and...
8.
Bussel J, Arnold D, Grossbard E, Mayer J, Trelinski J, Homenda W, et al.
Am J Hematol
. 2018 Apr;
93(7):921-930.
PMID: 29696684
Spleen tyrosine kinase (Syk) signaling is central to phagocytosis-based, antibody-mediated platelet destruction in adults with immune thrombocytopenia (ITP). Fostamatinib, an oral Syk inhibitor, produced sustained on-treatment responses in a phase...
9.
Jenkins Y, Sun T, Li Y, Markovtsov V, Uy G, Gross L, et al.
BMC Res Notes
. 2014 Sep;
7:674.
PMID: 25252968
Background: The novel small molecule R118 and the biguanide metformin, a first-line therapy for type 2 diabetes (T2D), both activate the critical cellular energy sensor 5'-AMP-activated protein kinase (AMPK) via...
10.
Baltgalvis K, White K, Li W, Claypool M, Lang W, Alcantara R, et al.
Am J Physiol Heart Circ Physiol
. 2014 Feb;
306(8):H1128-45.
PMID: 24561866
Intermittent claudication is a form of exercise intolerance characterized by muscle pain during walking in patients with peripheral artery disease (PAD). Endothelial cell and muscle dysfunction are thought to be...