Woojin An
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Explore the profile of Woojin An including associated specialties, affiliations and a list of published articles.
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61
Citations
2362
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Recent Articles
1.
Shin Y, Kim S, Choi T, Kim C, An W
Epigenetics Chromatin
. 2024 Nov;
17(1):35.
PMID: 39587626
Background: Bone remodeling is a continuous and balanced process which relies on the dynamic equilibrium between osteoclastic bone resorption and osteoblastic bone formation. During osteoclast differentiation, pro-osteoclastogenic and anti-osteoclastogenic genes...
2.
Shin Y, Kim S, An W
Sci Rep
. 2024 May;
14(1):11595.
PMID: 38773164
Despite growing evidence implicating the calcium-activated chloride channel anoctamin1 (ANO1) in cancer metastasis, its direct impact on the metastatic potential of prostate cancer and the possible significance of epigenetic alteration...
3.
Shin Y, Kim S, Liang G, An W
Mol Oncol
. 2024 Apr;
18(8):2001-2019.
PMID: 38600695
Matrix metalloproteinase 9 (MMP-9) is a member of the MMP family and has been recently identified as a nuclear protease capable of clipping histone H3 N-terminal tails (H3NT). This MMP-9-dependent...
4.
Sha L, Yang Z, An S, Yang W, Kim S, Oh H, et al.
Nat Cell Biol
. 2023 Nov;
25(11):1637-1649.
PMID: 37945831
Epigenetic dysregulation is a prominent feature in cancer, as exemplified by frequent mutations in chromatin regulators, including the MLL/KMT2 family of histone methyltransferases. Although MLL1/KMT2A activity on H3K4 methylation is...
5.
Shin Y, Kim S, Liang G, Ulmer T, An W
Biomedicines
. 2023 Sep;
11(9).
PMID: 37760992
Vpr binding protein (VprBP), also known as DDB1- and CUL4-associated factor1 (DCAF1), is a recently identified atypical kinase and plays an important role in downregulating the transcription of tumor suppressor...
6.
Shin Y, Kim S, Liang G, Ulmer T, An W
Res Sq
. 2023 Jun;
PMID: 37293029
Background: Melanoma is the most aggressive form of skin cancer arising from pigment-producing melanocytes and is often associated with dysregulation of epigenetic factors targeting histones. VprBP, also known as DCAF1,...
7.
Ghate N, Kim S, Shin Y, Kim J, Doche M, Valena S, et al.
Nat Commun
. 2023 Apr;
14(1):2140.
PMID: 37069142
Our recent work has shown that DCAF1 (also known as VprBP) is overexpressed in colon cancer and phosphorylates histone H2AT120 to drive epigenetic gene inactivation and oncogenic transformation. We have...
8.
Ghate N, Kim S, Mehmood R, Shin Y, Kim K, An W
Oncogene
. 2023 Apr;
42(17):1405-1416.
PMID: 37041410
VprBP (also known as DCAF1) is a recently identified kinase that is overexpressed in cancer cells and serves as a major determinant for epigenetic gene silencing and tumorigenesis. The role...
9.
Zhang L, Li H, Shereda R, Lu Q, Weisenberger D, OConnell C, et al.
Cancer Lett
. 2022 Sep;
548:215899.
PMID: 36087682
The development of more effective targeted therapies for hepatocellular carcinoma (HCC) patients due to its aggressiveness is urgently needed. DNA methyltransferase inhibitors (DNMTis) represented the first clinical breakthrough to target...
10.
Shin Y, Kim S, Ghate N, Rhie S, An W
Oncogene
. 2021 Nov;
41(4):560-570.
PMID: 34785776
Melanoma is a type of skin cancer that develops in pigment-producing melanocytes and often spreads to other parts of the body. Aberrant gene expression has been considered as a crucial...