Tobias S Ulmer
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Explore the profile of Tobias S Ulmer including associated specialties, affiliations and a list of published articles.
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Articles
54
Citations
2118
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Recent Articles
1.
Vu H, Situ A, Dai X, Ulmer T
Biochemistry
. 2025 Mar;
PMID: 40067740
In the innate immune system, the CD33 receptor modulates microglial activity. Its downregulation promises to slow Alzheimer's disease, and it is already targeted in blood cancers. The mechanism underlying CD33...
2.
Shin Y, Kim S, Liang G, Ulmer T, An W
Biomedicines
. 2023 Sep;
11(9).
PMID: 37760992
Vpr binding protein (VprBP), also known as DDB1- and CUL4-associated factor1 (DCAF1), is a recently identified atypical kinase and plays an important role in downregulating the transcription of tumor suppressor...
3.
Shin Y, Kim S, Liang G, Ulmer T, An W
Res Sq
. 2023 Jun;
PMID: 37293029
Background: Melanoma is the most aggressive form of skin cancer arising from pigment-producing melanocytes and is often associated with dysregulation of epigenetic factors targeting histones. VprBP, also known as DCAF1,...
4.
Situ A, Ulmer T
Biochemistry
. 2023 Jun;
62(12):1858-1863.
PMID: 37279176
Membrane proteins are commonly reconstituted in membrane mimics exhibiting discontinuous lipid bilayers. In contrast, the continuous membranes of cells are conceptually best represented by large unilamellar vesicles (LUVs). Here, we...
5.
Ghate N, Kim S, Shin Y, Kim J, Doche M, Valena S, et al.
Nat Commun
. 2023 Apr;
14(1):2140.
PMID: 37069142
Our recent work has shown that DCAF1 (also known as VprBP) is overexpressed in colon cancer and phosphorylates histone H2AT120 to drive epigenetic gene inactivation and oncogenic transformation. We have...
6.
Bravo-Arredondo J, Venkataraman R, Varkey J, Isas J, Situ A, Xu H, et al.
J Biol Chem
. 2023 Mar;
299(4):104616.
PMID: 36931390
Huntington's disease is caused by a polyglutamine (polyQ) expansion in the huntingtin protein. Huntingtin exon 1 (Httex1), as well as other naturally occurring N-terminal huntingtin fragments with expanded polyQ are...
7.
Vu H, Situ A, Ulmer T
Methods Mol Biol
. 2021 Apr;
2302:69-79.
PMID: 33877623
The ability to quantify protein-protein interactions without adding labels to protein has made isothermal titration calorimetry (ITC) a preferred technique to study proteins in aqueous solution. Here, we describe the...
8.
Situ A, Kim J, An W, Kim C, Ulmer T
J Mol Biol
. 2021 Feb;
433(7):166832.
PMID: 33539882
The inhibition of physiological activation pathways of the platelet adhesion receptor integrin αIIbβ3 may fail to prevent fatal thrombosis, suggesting that the receptor is at risk of activation by yet...
9.
Kim J, Lee J, Jang J, Ye F, Hong S, Petrich B, et al.
Curr Biol
. 2020 Jul;
30(13):2649.
PMID: 32634408
No abstract available.
10.
Kim J, Lee J, Jang J, Ye F, Hong S, Petrich B, et al.
Curr Biol
. 2020 Mar;
30(9):1614-1625.e5.
PMID: 32169208
Cells can sense and respond to various mechanical stimuli from their surrounding environment. One of the explanations for mechanosensitivity, a lipid-bilayer model, suggests that a stretch of the membrane induced...