Wen-Mei Yu
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Explore the profile of Wen-Mei Yu including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
1250
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Recent Articles
1.
Zheng H, Zhao P, Tan Z, Yu W, Werner J, Stieglitz E, et al.
Res Sq
. 2024 Aug;
PMID: 39149498
Juvenile myelomonocytic leukemia (JMML), a clonal hematologic malignancy, originates from mutated hematopoietic stem cells (HSCs). The mechanism sustaining the persistence of mutant stem cells, leading to leukemia development, remains elusive....
2.
Li D, Armand L, Sun F, Hwang H, Wolfson D, Rampoldi A, et al.
Stem Cell Res Ther
. 2023 Nov;
14(1):322.
PMID: 37941041
Background: Cardiac pathological outcome of metabolic remodeling is difficult to model using cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CMs) due to low metabolic maturation. Methods: hiPSC-CM spheres were treated...
3.
Ni F, Yu W, Li Z, Graham D, Jin L, Kang S, et al.
Nat Metab
. 2019 Sep;
1(3):390-403.
PMID: 31535081
Amino acid (AA) metabolism is involved in diverse cellular functions, including cell survival and growth, however it remains unclear how it regulates normal hematopoiesis versus leukemogenesis. Here, we report that...
4.
Gentillon C, Li D, Duan M, Yu W, Preininger M, Jha R, et al.
J Mol Cell Cardiol
. 2019 May;
132:120-135.
PMID: 31082397
Immature phenotypes of cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) limit the utility of these cells in clinical application and basic research. During cardiac development, postnatal cardiomyocytes experience...
5.
Ni F, Yu W, Wang X, Fay M, Young K, Qiu Y, et al.
Cell Stem Cell
. 2019 Mar;
24(4):608-620.e6.
PMID: 30880025
Hematopoietic stem cell (HSC) quiescence is a tightly regulated process crucial for hematopoietic regeneration, which requires a healthy and supportive microenvironmental niche within the bone marrow (BM). Here, we show...
6.
Zheng H, Yu W, Shen J, Kang S, Hambardzumyan D, Li J, et al.
Sci Adv
. 2018 Oct;
4(10):eaat2681.
PMID: 30338292
While deregulation of mitochondrial metabolism and cytosolic glycolysis has been well recognized in tumor cells, the role of coordinated mitochondrial oxidation and cytosolic fermentation of pyruvate, a key metabolite derived...
7.
Tarnawsky S, Yu W, Qu C, Chan R, Yoder M
Oncotarget
. 2018 May;
9(31):21831-21843.
PMID: 29774106
Juvenile Myelomonocytic Leukemia (JMML) is a pediatric myeloproliferative neoplasm (MPN) that has a poor prognosis. Somatic mutations in Ptpn11 are the most frequent cause of JMML and they commonly occur...
8.
Zheng H, Yu W, Waclaw R, Kontaridis M, Neel B, Qu C
Sci Signal
. 2018 Mar;
11(522).
PMID: 29559584
Catalytically activating mutations in , which encodes the protein tyrosine phosphatase SHP2, cause 50% of Noonan syndrome (NS) cases, whereas inactivating mutations in are responsible for nearly all cases of...
9.
Stavrou E, Fang C, Bane K, Long A, Naudin C, Kucukal E, et al.
J Clin Invest
. 2018 Jan;
128(3):944-959.
PMID: 29376892
Coagulation factor XII (FXII) deficiency is associated with decreased neutrophil migration, but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the inflammatory response. In 2 models of...
10.
Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, et al.
Mol Cell
. 2017 Dec;
69(1):87-99.e7.
PMID: 29249655
Loss of LKB1 is associated with increased metastasis and poor prognosis in lung cancer, but the development of targeted agents is in its infancy. Here we report that a glutaminolytic...