Wen-Mei Yu
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Explore the profile of Wen-Mei Yu including associated specialties, affiliations and a list of published articles.
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39
Citations
1250
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Recent Articles
11.
Dong L, Yu W, Zheng H, Loh M, Bunting S, Pauly M, et al.
Nature
. 2016 Nov;
539(7628):304-308.
PMID: 27783593
Germline activating mutations of the protein tyrosine phosphatase SHP2 (encoded by PTPN11), a positive regulator of the RAS signalling pathway, are found in 50% of patients with Noonan syndrome. These...
12.
Sabnis H, Bradley H, Tripathi S, Yu W, Tse W, Qu C, et al.
Leuk Res
. 2016 Oct;
50:132-140.
PMID: 27760406
Current therapy for acute myeloid leukemia (AML) primarily includes high-dose cytotoxic chemotherapy with or without allogeneic stem cell transplantation. Targeting unique cellular metabolism of cancer cells is a potentially less...
13.
Liu X, Zheng H, Yu W, Cooper T, Bunting K, Qu C
Blood
. 2015 Jan;
125(10):1562-5.
PMID: 25593337
The difficulty in maintaining the reconstituting capabilities of hematopoietic stem cells (HSCs) in culture outside of the bone marrow microenvironment has severely limited their utilization for clinical therapy. This hurdle...
14.
Li Q, Hakimi P, Liu X, Yu W, Ye F, Fujioka H, et al.
J Biol Chem
. 2013 Nov;
289(1):251-63.
PMID: 24265312
CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown to be essential for gluconeogenesis in the adult mouse. The metabolic function...
15.
Yu B, Liu W, Yu W, Loh M, Alter S, Guvench O, et al.
Mol Cancer Ther
. 2013 Jul;
12(9):1738-48.
PMID: 23825065
Activating mutations in PTPN11 (encoding SHP2), a protein tyrosine phosphatase (PTP) that plays an overall positive role in growth factor and cytokine signaling, are directly associated with the pathogenesis of...
16.
Xu D, Zheng H, Yu W, Qu C
PLoS One
. 2013 May;
8(5):e63152.
PMID: 23675459
Gain of function (GOF) mutations in protein tyrosine phosphatase Ptpn11 have been identified in childhood leukemias, and these mutations are sufficient to drive the development of myeloproliferative disorder and malignant...
17.
Yu W, Liu X, Shen J, Jovanovic O, Pohl E, Gerson S, et al.
Cell Stem Cell
. 2013 Jan;
12(1):62-74.
PMID: 23290137
The regulation and coordination of mitochondrial metabolism with hematopoietic stem cell (HSC) self-renewal and differentiation is not fully understood. Here we report that depletion of PTPMT1, a PTEN-like mitochondrial phosphatase,...
18.
Wang J, Ma J, Yu W, Li X
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
. 2011 Dec;
23(2):206, 210.
PMID: 22164631
A schistosomiasis surveillance was performed with the Oncomelania snail survey and suspected patient survey in Jiaxing City, 2009. There were snails in 3 villages of 2 counties and the airport...
19.
Shen J, Liu X, Yu W, Liu J, Groot Nibbelink M, Guo C, et al.
Mol Cell Biol
. 2011 Oct;
31(24):4902-16.
PMID: 21986498
Mitochondria are highly dynamic organelles that play multiple roles in cells. How mitochondria cooperatively modulate embryonic stem (ES) cell function during development is not fully understood. Global disruption of Ptpmt1,...
20.
Xu D, Liu X, Yu W, Meyerson H, Guo C, Gerson S, et al.
J Exp Med
. 2011 Sep;
208(10):1977-88.
PMID: 21930766
Activating mutations in protein tyrosine phosphatase 11 (Ptpn11) have been identified in childhood acute leukemias, in addition to juvenile myelomonocytic leukemia (JMML), which is a myeloproliferative disorder (MPD). It is...