Cheng-Kui Qu
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Explore the profile of Cheng-Kui Qu including associated specialties, affiliations and a list of published articles.
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86
Citations
2210
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Recent Articles
1.
Wu M, Yang H, Liu S, Jiang L, Liang T, Wang Y, et al.
Nat Biomed Eng
. 2024 Dec;
PMID: 39715892
The engraftment of haematopoietic stem and progenitor cells (HSPCs), particularly in cord-blood transplants, remains challenging. Here we report the role of the corticotropin-releasing hormone (CRH) in enhancing the homing and...
2.
Zheng H, Zhao P, Tan Z, Yu W, Werner J, Stieglitz E, et al.
Res Sq
. 2024 Aug;
PMID: 39149498
Juvenile myelomonocytic leukemia (JMML), a clonal hematologic malignancy, originates from mutated hematopoietic stem cells (HSCs). The mechanism sustaining the persistence of mutant stem cells, leading to leukemia development, remains elusive....
3.
Chouhan S, Sridaran D, Weimholt C, Luo J, Li T, Hodgson M, et al.
Nat Commun
. 2024 Jul;
15(1):5629.
PMID: 38965223
Mutations that decrease or increase the activity of the tyrosine phosphatase, SHP2 (encoded by PTPN11), promotes developmental disorders and several malignancies by varying phosphatase activity. We uncovered that SHP2 is...
4.
Chen C, Zheng H, Horwitz E, Ando S, Araki K, Zhao P, et al.
Sci Adv
. 2023 Dec;
9(49):eadf9522.
PMID: 38055827
Mitochondria use different substrates for energy production and intermediatory metabolism according to the availability of nutrients and oxygen levels. The role of mitochondrial metabolic flexibility for CD8 T cell immune...
5.
Li D, Armand L, Sun F, Hwang H, Wolfson D, Rampoldi A, et al.
Stem Cell Res Ther
. 2023 Nov;
14(1):322.
PMID: 37941041
Background: Cardiac pathological outcome of metabolic remodeling is difficult to model using cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CMs) due to low metabolic maturation. Methods: hiPSC-CM spheres were treated...
6.
Zheng H, Li Q, Li S, Li Z, Brotto M, Weiss D, et al.
Elife
. 2023 Sep;
12.
PMID: 37672386
While mitochondria in different tissues have distinct preferences for energy sources, they are flexible in utilizing competing substrates for metabolism according to physiological and nutritional circumstances. However, the regulatory mechanisms...
7.
Yan Y, Chen C, Li Z, Zhang J, Park N, Qu C
Sci Rep
. 2022 Dec;
12(1):21832.
PMID: 36528691
Amino acid-mediated metabolism is one of the key catabolic and anabolic processes involved in diverse cellular functions. However, the role of the semi-essential amino acid arginine in normal and malignant...
8.
Zhang R, Chen D, Fan H, Wu R, Tu J, Zhang F, et al.
Cell Chem Biol
. 2022 Apr;
29(7):1200-1208.e6.
PMID: 35429459
Environmental stresses, including hypoxia or detachment for anchorage independence, or attenuation of mitochondrial respiration through inhibition of electron transport chain induce reductive carboxylation in cells with an enhanced fraction of...
9.
Yan Y, Dong L, Chen C, Bunting K, Li Q, Stieglitz E, et al.
Blood Adv
. 2021 Sep;
6(1):200-206.
PMID: 34555844
Development of normal blood cells is often suppressed in juvenile myelomonocytic leukemia (JMML), a myeloproliferative neoplasm (MPN) of childhood, causing complications and impacting therapeutic outcomes. However, the mechanism underlying this...
10.
Su H, Jiang M, Senevirathne C, Aluri S, Zhang T, Guo H, et al.
Cell Rep
. 2021 Jul;
36(4):109421.
PMID: 34320342
Mitogen-activated protein kinases (MAPKs) are inactivated by dual-specificity phosphatases (DUSPs), the activities of which are tightly regulated during cell differentiation. Using knockdown screening and single-cell transcriptional analysis, we demonstrate that...