Wen-Jian Tang
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Explore the profile of Wen-Jian Tang including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
179
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Recent Articles
1.
Cai L, Mu Y, Liu M, Tang W, Li R
Int Immunopharmacol
. 2020 Jan;
80:106182.
PMID: 31981962
We previously reported that penta-acetyl geniposide ((Ac)GP, an acetylated derivative of geniposide) exhibited better pharmacological functions than geniposide, a major active component of Gardenia jasminoides Ellis. This study demonstrated the...
2.
Li C, Tang W, Feng W, Liu C, Song Q
Anal Chim Acta
. 2019 Dec;
1096:148-158.
PMID: 31883581
Nitric oxide (NO) is a very important signal molecule implicated in numerous physiological and pathological processes, and its detection is the key to understand these processes. For this reason, various...
3.
Chen X, Tang W, Shi J, Liu M, Liu X
Med Res Rev
. 2019 Jul;
40(2):532-585.
PMID: 31361345
Telomere and telomerase play important roles in abnormal cell proliferation, metastasis, stem cell maintenance, and immortalization in various cancers. Therefore, designing of drugs targeting telomerase and telomere is of great...
4.
Qiu G, He S, Chen S, Li B, Wu H, Zhang J, et al.
J Enzyme Inhib Med Chem
. 2018 Oct;
33(1):1506-1515.
PMID: 30284486
Based on the structural analysis of tricyclic scaffolds as butyrylcholinesterase (BuChE) inhibitors, a series of pyrazolo[1,5-c][1,3]benzoxazin-5(5H)-one derivatives were designed, synthesized and evaluated for their acetylcholinesterase (AChE) and BuChE inhibitory activity....
5.
Cai L, Li C, Tang W, Liu M, Chen W, Qiu Y, et al.
Inflammation
. 2018 Aug;
41(6):2184-2195.
PMID: 30069664
Previous studies demonstrated that penta-acetyl geniposide ((Ac)GP, an acetylated derivative of geniposide) exhibited better pharmacological functions than geniposide. This study was aimed to observe the potential effect of (Ac)GP on...
6.
Chen S, Qiu G, Li B, Shi J, Liu X, Tang W
Eur J Med Chem
. 2018 Feb;
147:194-204.
PMID: 29438888
BuChE inhibitors play important roles in treatment of patients with advanced Alzheimer's disease (AD). A series of tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one derivatives were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)...
7.
Li B, Cai S, Yang Y, Chen S, Chen R, Shi J, et al.
Eur J Med Chem
. 2017 Aug;
139:337-348.
PMID: 28803048
To develop novel anti-inflammatory agents, a series of unsaturated glycyrrhetic acids were designed, synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells. The structure-activity relationship (SAR) of NO inhibitory activity...
8.
Ma J, Li H, Zhang X, Tang W, Li M, Lee Phillips D
J Org Chem
. 2016 Sep;
81(20):9553-9559.
PMID: 27661756
Recent studies conducted on some "meta effect" photochemical reactions focused on aromatic carbonyls having a substitution on one meta position of the benzophenone (BP) and anthraquinone parent compound. In this...
9.
Chen R, Xiao J, Ni Y, Xu H, Zheng M, Tong X, et al.
Bioorg Med Chem
. 2016 Mar;
24(8):1741-8.
PMID: 26964672
Based on our recently reported selective hMAO-A inhibitors, on which, the intramolecular cyclization led to a very interesting change of isoform selectivity. A series of selective hMAO-B inhibitors (3a-3u) with...
10.
Wang Q, Shi J, Chen C, Huang C, Tang W, Li J
Bioorg Med Chem Lett
. 2016 Feb;
26(5):1460-5.
PMID: 26848111
Sixteen novel hesperetin derivatives containing Mannich base moiety were designed and synthesized and their anti-inflammatory activities were evaluated by inhibiting tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in mouse RAW264.7...