Wareed Ahmed
Overview
Explore the profile of Wareed Ahmed including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
387
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0
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Recent Articles
11.
Ahmed W, Menon S, Karthik P, Nagaraja V
Nucleic Acids Res
. 2015 Oct;
44(4):1541-52.
PMID: 26496944
The opposing catalytic activities of topoisomerase I (TopoI/relaxase) and DNA gyrase (supercoiling enzyme) ensure homeostatic maintenance of bacterial chromosome supercoiling. Earlier studies in Escherichia coli suggested that the alteration in...
12.
Godbole A, Ahmed W, Bhat R, Bradley E, Ekins S, Nagaraja V
Antimicrob Agents Chemother
. 2014 Dec;
59(3):1549-57.
PMID: 25534741
We describe inhibition of Mycobacterium tuberculosis topoisomerase I (MttopoI), an essential mycobacterial enzyme, by two related compounds, imipramine and norclomipramine, of which imipramine is clinically used as an antidepressant. These...
13.
Ahmed W, Menon S, Karthik P, Nagaraja V
Microbiology (Reading)
. 2014 Dec;
161(Pt 2):341-353.
PMID: 25516959
The steady-state negative supercoiling of eubacterial genomes is maintained by the action of DNA topoisomerases. Topoisomerase distribution varies in different species of mycobacteria. While Mycobacterium tuberculosis (Mtb) contains a single...
14.
Godbole A, Ahmed W, Bhat R, Bradley E, Ekins S, Nagaraja V
Biochem Biophys Res Commun
. 2014 Mar;
446(4):916-20.
PMID: 24642256
m-AMSA, an established inhibitor of eukaryotic type II topoisomerases, exerts its cidal effect by binding to the enzyme-DNA complex thus inhibiting the DNA religation step. The molecule and its analogues...
15.
Ahmed W, Menon S, Godbole A, Karthik P, Nagaraja V
FEMS Microbiol Lett
. 2014 Mar;
353(2):116-23.
PMID: 24593153
Topoisomerases are an important class of enzymes for regulating the DNA transaction processes. Mycobacterium tuberculosis (Mtb) is one of the most formidable pathogens also posing serious challenges for therapeutic interventions....
16.
Ahmed W, Bhat A, Leelaram M, Menon S, Nagaraja V
Nucleic Acids Res
. 2013 Jun;
41(15):7462-71.
PMID: 23771144
Bacterial DNA topoisomerase I (topoI) carries out relaxation of negatively supercoiled DNA through a series of orchestrated steps, DNA binding, cleavage, strand passage and religation. The N-terminal domain (NTD) of...