Adwait Anand Godbole
Overview
Explore the profile of Adwait Anand Godbole including associated specialties, affiliations and a list of published articles.
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11
Citations
144
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Recent Articles
1.
Franch O, Han X, Marcussen L, Givskov A, Andersen M, Godbole A, et al.
Nanoscale
. 2018 Dec;
11(2):587-597.
PMID: 30556557
In the current study, we describe a novel DNA sensor system for specific and quantitative detection of mycobacteria, which is the causative agent of tuberculosis. Detection is achieved by using...
2.
Mori G, Orena B, Franch C, Mitchenall L, Godbole A, Rodrigues L, et al.
Tuberculosis (Edinb)
. 2018 Sep;
112:98-109.
PMID: 30205975
The search for compounds with biological activity for many diseases is turning increasingly to drug repurposing. In this study, we have focused on the European Union-approved antimalarial pyronaridine which was...
3.
Ekins S, Godbole A, Keri G, Orfi L, Pato J, Bhat R, et al.
Tuberculosis (Edinb)
. 2017 Feb;
103:52-60.
PMID: 28237034
There is a shortage of compounds that are directed towards new targets apart from those targeted by the FDA approved drugs used against Mycobacterium tuberculosis. Topoisomerase I (Mttopo I) is...
4.
Ghosh S, Padmanabhan B, Godbole A, Tare P, Ahmed W, Vasu K, et al.
Biochem Biophys Res Commun
. 2016 May;
475(3):257-63.
PMID: 27207833
Mycobacterium tuberculosis (Mtb) is a formidable pathogen which has the ability to survive the hostile environment of the host by evading the host defense system. The re-configuration of its transcriptional...
5.
Jepsen M, Harmsen C, Godbole A, Nagaraja V, Knudsen B, Ho Y
Nanoscale
. 2015 Dec;
8(1):358-64.
PMID: 26616006
We present a quantum dot based DNA nanosensor specifically targeting the cleavage step in the reaction cycle of the essential DNA-modifying enzyme, mycobacterial topoisomerase I. The design takes advantages of...
6.
Sipos A, Pato J, Szekely R, Hartkoorn R, Kekesi L, Orfi L, et al.
Tuberculosis (Edinb)
. 2015 Mar;
95 Suppl 1:S200-6.
PMID: 25801335
Discovering new drugs to treat tuberculosis more efficiently and to overcome multidrug resistance is a world health priority. To find novel antitubercular agents several approaches have been used in various...
7.
Godbole A, Ahmed W, Bhat R, Bradley E, Ekins S, Nagaraja V
Antimicrob Agents Chemother
. 2014 Dec;
59(3):1549-57.
PMID: 25534741
We describe inhibition of Mycobacterium tuberculosis topoisomerase I (MttopoI), an essential mycobacterial enzyme, by two related compounds, imipramine and norclomipramine, of which imipramine is clinically used as an antidepressant. These...
8.
Godbole A, Ahmed W, Bhat R, Bradley E, Ekins S, Nagaraja V
Biochem Biophys Res Commun
. 2014 Mar;
446(4):916-20.
PMID: 24642256
m-AMSA, an established inhibitor of eukaryotic type II topoisomerases, exerts its cidal effect by binding to the enzyme-DNA complex thus inhibiting the DNA religation step. The molecule and its analogues...
9.
Ahmed W, Menon S, Godbole A, Karthik P, Nagaraja V
FEMS Microbiol Lett
. 2014 Mar;
353(2):116-23.
PMID: 24593153
Topoisomerases are an important class of enzymes for regulating the DNA transaction processes. Mycobacterium tuberculosis (Mtb) is one of the most formidable pathogens also posing serious challenges for therapeutic interventions....
10.
Leelaram M, Bhat A, Godbole A, Bhat R, Manjunath R, Nagaraja V
FASEB J
. 2013 Apr;
27(8):3030-8.
PMID: 23612788
Bacterial DNA topoisomerase I (topoI) catalyzes relaxation of negatively supercoiled DNA. The enzyme alters DNA topology through protein-operated DNA gate, switching between open and closed conformations during its reaction. We...