Joachim Lingner
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Explore the profile of Joachim Lingner including associated specialties, affiliations and a list of published articles.
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82
Citations
5024
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Recent Articles
1.
Kyriacou E, Lingner J
Curr Opin Cell Biol
. 2024 Sep;
91:102437.
PMID: 39342869
TERRA long noncoding RNAs play key roles in telomere function and maintenance. They can orchestrate telomeric chromatin remodeling, regulate telomere maintenance by telomerase and homology-directed repair, and they participate in...
2.
Fernandes R, Lingner J
Nucleic Acids Res
. 2023 May;
51(13):6702-6722.
PMID: 37246640
Telomeres are the nucleoprotein structures at the ends of linear chromosomes. Telomeres are transcribed into long non-coding Telomeric Repeat-Containing RNA (TERRA), whose functions rely on its ability to associate with...
3.
Glousker G, Lingner J
Genes Dev
. 2022 Nov;
36(17-18):951-953.
PMID: 36347559
Although telomeres are essential for chromosome stability, they represent fragile structures in our genome. Telomere shortening occurs during aging in cells lacking telomerase due to the end replication problem. In...
4.
Glousker G, Fernandes R, Feretzaki M, Lingner J
Methods Mol Biol
. 2022 Jun;
2528:159-171.
PMID: 35704191
R-loops are three-stranded nucleic acid structures composed of a DNA-RNA hybrid and a displaced DNA strand. The long noncoding RNA TERRA forms R-loops at telomeres influencing the telomeric chromatin composition...
5.
Lin C, Nager A, Lunardi T, Vancevska A, Lossaint G, Lingner J
Nucleic Acids Res
. 2021 Nov;
49(21):12119-12135.
PMID: 34747482
Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can...
6.
Glousker G, Lingner J
Bioessays
. 2021 Aug;
43(10):e2100157.
PMID: 34436787
It has become apparent that difficulties to replicate telomeres concern not only the very ends of eukaryotic chromosomes. The challenges already start when the replication fork enters the telomeric repeats....
7.
Fernandes R, Feretzaki M, Lingner J
Cell Cycle
. 2021 Aug;
20(18):1745-1759.
PMID: 34432566
Telomeres protect chromosome ends from nucleolytic degradation, uncontrolled recombination by DNA repair enzymes and checkpoint signaling, and they provide mechanisms for their maintenance by semiconservative DNA replication, telomerase and homologous...
8.
Mentegari E, Bertoletti F, Kissova M, Zucca E, Galli S, Tagliavini G, et al.
Int J Mol Sci
. 2021 Mar;
22(5).
PMID: 33673424
Telomerase negative cancer cell types use the Alternative Lengthening of Telomeres (ALT) pathway to elongate telomeres ends. Here, we show that silencing human DNA polymerase (Pol λ) in ALT cells...
9.
Ahmed W, Lingner J
Cell Rep
. 2020 Nov;
33(5):108347.
PMID: 33147465
Telomeres are prone to damage inflicted by reactive oxygen species (ROS). Oxidized telomeric DNA and nucleotide substrates inhibit telomerase, causing telomere shortening. In addition, ROS can induce telomeric single-strand DNA...
10.
Glousker G, Briod A, Quadroni M, Lingner J
EMBO J
. 2020 Oct;
39(23):e104500.
PMID: 33073402
The evolutionarily conserved POT1 protein binds single-stranded G-rich telomeric DNA and has been implicated in contributing to telomeric DNA maintenance and the suppression of DNA damage checkpoint signaling. Here, we...