Rajiv Kumar Jha
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Explore the profile of Rajiv Kumar Jha including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
408
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Recent Articles
1.
Das S, Karmakar S, Venkatachalapathy H, Jha R, Batchelor E, Levens D
Mol Cell
. 2024 Oct;
84(21):4059-4078.e10.
PMID: 39481385
Hyperproliferation driven by the protooncogene MYC may lead to tumor suppressor p53 activating DNA damage that has been presumed to derive from hypertranscription and over-replication. Here, we report that excessive...
2.
Jha R, Kouzine F, Levens D
Front Cell Dev Biol
. 2023 Nov;
11:1268275.
PMID: 37941901
MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier that regulates almost every physiological process in a cell including cell cycle, proliferation, metabolism, differentiation, and apoptosis....
3.
Lewis B, Das S, Jha R, Levens D
Sci Adv
. 2023 Oct;
9(42):eadi4565.
PMID: 37851801
Transcription in the nucleus occurs in a concentrated, dense environment, and no reasonable biochemical facsimile of this milieu exists. Such a biochemical environment would be important for further understanding transcriptional...
4.
Dobrovolskaite A, Moots H, Tantak M, Shah K, Thomas J, Dinara S, et al.
J Med Chem
. 2022 Nov;
65(22):15391-15415.
PMID: 36382923
Polyamine biosynthesis is regulated by ornithine decarboxylase (ODC), which is transcriptionally activated by c-Myc. A large library was screened to find molecules that potentiate the ODC inhibitor, difluoromethylornithine (DFMO). Anthranilic...
5.
Chen D, Wei X, Yang K, Liu X, Song Y, Bai F, et al.
J Int Med Res
. 2022 Apr;
50(4):3000605221093308.
PMID: 35481419
Objective: To investigate the effects of piperlongumine (PL) and vitamin C (VC) on signal transducer and activator of transcription 3 (STAT3) signalling in gastric cancer cell lines. Methods: tumour xenograft...
6.
Jha R, Levens D, Kouzine F
Nucleus
. 2022 Feb;
13(1):94-115.
PMID: 35220881
The compaction of linear DNA into micrometer-sized nuclear boundaries involves the establishment of specific three-dimensional (3D) DNA structures complexed with histone proteins that form chromatin. The resulting structures modulate essential...
7.
Das S, Kuzin V, Cameron D, Sanford S, Jha R, Nie Z, et al.
Mol Cell
. 2021 Dec;
82(1):140-158.e12.
PMID: 34890565
High-intensity transcription and replication supercoil DNA to levels that can impede or halt these processes. As a potent transcription amplifier and replication accelerator, the proto-oncogene MYC must manage this interfering...
8.
Zhou Y, Lin B, Li K, Zhao Y, Sun Z, He C, et al.
Front Oncol
. 2021 Oct;
11:750807.
PMID: 34604095
At present, the clinical diagnosis of and treatment methods for hepatic carcinoma still fail to fully meet the needs of patients. The integrated theranostic system, in which functional materials are...
9.
Anand K, Tripathi A, Shukla K, Malhotra N, Jamithireddy A, Jha R, et al.
Redox Biol
. 2021 Aug;
46:102062.
PMID: 34392160
The persistence of Mycobacterium tuberculosis (Mtb) is a major problem in managing tuberculosis (TB). Host-generated nitric oxide (NO) is perceived as one of the signals by Mtb to reprogram metabolism...
10.
Zhang X, Lian T, Fan W, Zhang G, Chen Z, Gou X, et al.
Cancer Manag Res
. 2020 Oct;
12:9033-9043.
PMID: 33061598
Objective: The long-noncoding RNAs (lncRNAs) have been identified as key players in diverse cellular processes in non-small cell lung cancer (NSCLC). However, the understanding of biological functions and detailed mechanisms...