Wareed Ahmed
Overview
Explore the profile of Wareed Ahmed including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
387
Followers
0
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Recent Articles
1.
Ahmad E, Mitra A, Ahmed W, Mahapatra V, Hegde S, Sala C, et al.
Biochim Biophys Acta Gene Regul Mech
. 2023 Feb;
1866(2):194923.
PMID: 36822574
Intrinsic and Rho-dependent transcription termination mechanisms regulate gene expression and recycle RNA polymerase in bacteria. Both the modes are well studied in Escherichia coli, and a few other organisms. The...
2.
Ahmed W, Lingner J
Cell Rep
. 2020 Nov;
33(5):108347.
PMID: 33147465
Telomeres are prone to damage inflicted by reactive oxygen species (ROS). Oxidized telomeric DNA and nucleotide substrates inhibit telomerase, causing telomere shortening. In addition, ROS can induce telomeric single-strand DNA...
3.
Vancevska A, Ahmed W, Pfeiffer V, Feretzaki M, Boulton S, Lingner J
EMBO J
. 2020 Feb;
39(7):e102668.
PMID: 32080884
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1) has been implicated in X-chromosome inactivation, imprinting, and DNA damage repair, and mutations in SMCHD1 can cause facioscapulohumeral muscular dystrophy....
4.
Datta C, Jha R, Ahmed W, Ganguly S, Ghosh S, Nagaraja V
Mol Microbiol
. 2019 Jan;
111(4):981-994.
PMID: 30633392
Nucleoid-associated proteins (NAPs) in bacteria contribute to key activities such as DNA compaction, chromosome organization and regulation of gene expression. HU and Lsr2 are two principal NAPs in Mycobacterium tuberculosis...
5.
Guha S, Udupa S, Ahmed W, Nagaraja V
J Mol Biol
. 2018 Oct;
430(24):4986-5001.
PMID: 30316784
DNA gyrase, essential for DNA replication and transcription, has traditionally been studied in vivo by treatments that inhibit the enzyme activity. Due to its indispensable function, gyrA and gyrB deletions...
6.
Ahmed W, Lingner J
Genes Dev
. 2018 May;
32(9-10):658-669.
PMID: 29773556
Telomerase counteracts telomere shortening and cellular senescence in germ, stem, and cancer cells by adding repetitive DNA sequences to the ends of chromosomes. Telomeres are susceptible to damage by reactive...
7.
Ahmed W, Lingner J
Differentiation
. 2017 Dec;
99:21-27.
PMID: 29274896
Telomere integrity is essential for genome stability and it regulates cell proliferation and tissue renewal. Several lines of evidence indicate that telomeres are particularly sensitive to oxidative damage. Moreover, recent...
8.
Ahmed W, Sala C, Hegde S, Jha R, Cole S, Nagaraja V
PLoS Genet
. 2017 May;
13(5):e1006754.
PMID: 28463980
Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils generated ahead of transcribing RNA polymerase (RNAP) and...
9.
Aeby E, Ahmed W, Redon S, Simanis V, Lingner J
Cell Rep
. 2016 Dec;
17(12):3107-3114.
PMID: 28009281
Oxidative damage of telomeres can promote cancer, cardiac failure, and muscular dystrophy. Specific mechanisms protecting telomeres from oxidative damage have not been described. We analyzed telomeric chromatin composition during the...
10.
Ghosh S, Padmanabhan B, Godbole A, Tare P, Ahmed W, Vasu K, et al.
Biochem Biophys Res Commun
. 2016 May;
475(3):257-63.
PMID: 27207833
Mycobacterium tuberculosis (Mtb) is a formidable pathogen which has the ability to survive the hostile environment of the host by evading the host defense system. The re-configuration of its transcriptional...