Tom Huxford
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Explore the profile of Tom Huxford including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
998
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Recent Articles
21.
King A, Fleming J, Knapik S, Visentin B, Wojciak J, Huxford T
J Lipid Res
. 2017 May;
58(7):1386-1398.
PMID: 28507038
Cysteinyl leukotrienes (CysLTs) are a small family of biological signaling lipids produced by active leukocytes that contribute to diverse inflammatory disease states as a consequence of their engagement with dedicated...
22.
Geronimo I, Denning C, Rogers W, Othman T, Huxford T, Heidary D, et al.
Biochemistry
. 2016 Jun;
55(25):3594-606.
PMID: 27267136
Cytochrome P450BM3 is a heme-containing enzyme from Bacillus megaterium that exhibits high monooxygenase activity and has a self-sufficient electron transfer system in the full-length enzyme. Its potential synthetic applications drive...
23.
Hauenstein A, Rogers W, Shaul J, Huang D, Ghosh G, Huxford T
Biochemistry
. 2014 Mar;
53(12):2064-73.
PMID: 24611898
Catalytic subunits of the IκB kinase (IKK), IKK1/IKKα, and IKK2/IKKβ function in vivo as dimers in association with the necessary scaffolding subunit NEMO/IKKγ. Recent X-ray crystal structures of IKK2 suggested...
24.
Weerasinghe A, Amin S, Barker R, Othman T, Romano A, Parker Siburt C, et al.
J Am Chem Soc
. 2013 Sep;
135(39):14504-7.
PMID: 24028339
Boron in the ocean is generally considered a nonbiological element due to its relatively high concentration (0.4 mM) and depth independent concentration profile. Here we report an unexpected role for...
25.
Polley S, Huang D, Hauenstein A, Fusco A, Zhong X, Vu D, et al.
PLoS Biol
. 2013 Jun;
11(6):e1001581.
PMID: 23776406
Activation of the IκB kinase (IKK) is central to NF-κB signaling. However, the precise activation mechanism by which catalytic IKK subunits gain the ability to induce NF-κB transcriptional activity is...
26.
Caldwell J, Melkani G, Huxford T, Bernstein S
Methods
. 2011 Dec;
56(1):25-32.
PMID: 22178692
Biophysical and structural studies on muscle myosin rely upon milligram quantities of extremely pure material. However, many biologically interesting myosin isoforms are expressed at levels that are too low for...
27.
Lee C, Hauenstein A, Fleming J, Gasper W, Engelke V, Sankaran B, et al.
Structure
. 2011 Mar;
19(3):397-408.
PMID: 21397190
UCS proteins, such as UNC-45, influence muscle contraction and other myosin-dependent motile processes. We report the first X-ray crystal structure of a UCS domain-containing protein, the UNC-45 myosin chaperone from...
28.
Fleming J, Wojciak J, Campbell M, Huxford T
J Mol Biol
. 2011 Mar;
408(3):462-76.
PMID: 21392506
Lysophosphatidic acid (LPA) is a common product of glycerophospholipid metabolism and an important mediator of signal transduction. Aberrantly high LPA concentrations accompany multiple disease states. One potential approach for treatment...
29.
Huxford T, Hoffmann A, Ghosh G
Curr Top Microbiol Immunol
. 2010 Sep;
349:1-24.
PMID: 20845107
NF-κB is an inducible transcription factor that controls expression of diverse stress response genes. The entire mammalian NF-κB family is generated from a small cadre of five gene products that...
30.
Huxford T, Ghosh G
Cold Spring Harb Perspect Biol
. 2010 Jan;
1(3):a000075.
PMID: 20066103
The prosurvival transcription factor NF-kappaB specifically binds promoter DNA to activate target gene expression. NF-kappaB is regulated through interactions with IkappaB inhibitor proteins. Active proteolysis of these IkappaB proteins is,...