Tom Huxford
Overview
Explore the profile of Tom Huxford including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
998
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Recent Articles
31.
Wojciak J, Zhu N, Schuerenberg K, Moreno K, Shestowsky W, Hiraiwa M, et al.
Proc Natl Acad Sci U S A
. 2009 Oct;
106(42):17717-22.
PMID: 19815502
The pleiotropic signaling lipid sphingosine-1-phosphate (S1P) plays significant roles in angiogenesis, heart disease, and cancer. LT1009 (also known as sonepcizumab) is a humanized monoclonal antibody that binds S1P with high...
32.
Shaul J, Farina A, Huxford T
Biochem Biophys Res Commun
. 2008 Jul;
374(3):592-7.
PMID: 18657515
NF-kappaB activation in response to pro-inflammatory stimuli relies upon phosphorylation of IkappaB alpha at serines 32 and 36 by the beta subunit of the IkappaB kinase complex (IKK). In this...
33.
Trinh D, Zhu N, Farhang G, Kim B, Huxford T
J Mol Biol
. 2008 Apr;
379(1):122-35.
PMID: 18436238
Although they share sequence homology to classical cytoplasmic I kappaB inhibitors of transcription factor NF-kappaB, the proteins I kappaB zeta, Bcl-3, and I kappa BNS function in the nucleus as...
34.
Bourne Y, Hansen S, Sulzenbacher G, Talley T, Huxford T, Taylor P, et al.
J Mol Neurosci
. 2006 Dec;
30(1-2):103-4.
PMID: 17192648
Many peptidic toxins from animal venoms target neuronal or peripheral synaptic receptors with high affinities and specificities. Hence, these toxins are not only potent natural weapons but also precise molecular...
35.
Hansen S, Sulzenbacher G, Huxford T, Marchot P, Bourne Y, Taylor P
J Mol Neurosci
. 2006 Dec;
30(1-2):101-2.
PMID: 17192647
Nicotinic acetylcholine receptors (nAChRs) are well-characterized allosteric transmembrane proteins involved in the rapid gating of ions elicited by ACh. These receptors belong to the Cys-loop superfamily of ligand-gated ion channels,...
36.
Huxford T, Ghosh G
Methods Enzymol
. 2006 Jun;
407:527-34.
PMID: 16757350
kappaB-Ras1 and kappaB-Ras2 are two small proteins that display similarity at the amino acid level to Ras-like small GTPases. Although little is known about the function of the kappaB-Ras proteins,...
37.
Bergqvist S, Croy C, Kjaergaard M, Huxford T, Ghosh G, Komives E
J Mol Biol
. 2006 Jun;
360(2):421-34.
PMID: 16756995
IkappaBalpha is an ankyrin repeat protein that inhibits NF-kappaB transcriptional activity by sequestering NF-kappaB outside of the nucleus in resting cells. We have characterized the binding thermodynamics and kinetics of...
38.
Hansen S, Sulzenbacher G, Huxford T, Marchot P, Taylor P, Bourne Y
EMBO J
. 2005 Sep;
24(20):3635-46.
PMID: 16193063
Upon ligand binding at the subunit interfaces, the extracellular domain of the nicotinic acetylcholine receptor undergoes conformational changes, and agonist binding allosterically triggers opening of the ion channel. The soluble...
39.
Croy C, Bergqvist S, Huxford T, Ghosh G, Komives E
Protein Sci
. 2004 Jun;
13(7):1767-77.
PMID: 15215520
The crystal structure of IkappaBalpha in complex with the transcription factor, nuclear factor kappa-B (NF-kappaB) shows six ankyrin repeats, which are all ordered. Electron density was not observed for most...
40.
Ghosh G, Huang D, Huxford T
Curr Opin Struct Biol
. 2004 Apr;
14(1):21-7.
PMID: 15102445
During the past two decades, structural and biophysical studies of DNA-protein and RNA-protein complexes have enhanced our understanding of the physico-chemical basis of nucleic acid recognition by proteins. However, it...