Thomas J Wandless
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Explore the profile of Thomas J Wandless including associated specialties, affiliations and a list of published articles.
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55
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3642
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Recent Articles
1.
Park J, Wandless T
bioRxiv
. 2024 Nov;
PMID: 39574672
Exposure to exogenous and endogenous stress is associated with the intracellular accumulation of aberrant unfolded and misfolded proteins. In eukaryotic cells, protein homeostasis within membrane-bound organelles is regulated by specialized...
2.
Sidoli M, Chen L, Lu A, Wandless T, Talbot W
ACS Chem Biol
. 2024 Mar;
19(4):1022.
PMID: 38456802
No abstract available.
3.
Utsugi Y, Nishimura K, Yamanaka S, Nishino K, Kosako H, Sawasaki T, et al.
ACS Chem Biol
. 2024 Jan;
19(2):497-505.
PMID: 38270585
The chemogenetic control of cellular protein stability using degron tags is a powerful experimental strategy in biomedical research. However, this technique requires permanent fusion of the degron to a target...
4.
Sidoli M, Chen L, Lu A, Wandless T, Talbot W
ACS Chem Biol
. 2022 Jul;
17(8):2024-2030.
PMID: 35839076
cAMP is a ubiquitous second messenger with many functions in diverse organisms. Current cAMP sensors, including Föster resonance energy transfer (FRET)-based and single-wavelength-based sensors, allow for real time visualization of...
5.
Weber E, Parker K, Sotillo E, Lynn R, Anbunathan H, Lattin J, et al.
Science
. 2021 Apr;
372(6537).
PMID: 33795428
T cell exhaustion limits immune responses against cancer and is a major cause of resistance to chimeric antigen receptor (CAR)-T cell therapeutics. Using murine xenograft models and an in vitro...
6.
Miyamae Y, Chen L, Utsugi Y, Farrants H, Wandless T
Cell Chem Biol
. 2020 Oct;
27(12):1573-1581.e3.
PMID: 33007216
Here, we report a method to regulate cellular protein levels by introducing a ubiquitin variant between a destabilizing domain (DD) and the regulated protein. When produced in the absence of...
7.
Navarro R, Chen L, Rakhit R, Wandless T
ACS Chem Biol
. 2016 Jun;
11(8):2101-4.
PMID: 27243964
Tools that can directly regulate the activity of any protein-of-interest are valuable in the study of complex biological processes. Herein, we describe the development of a novel protein domain that...
8.
Miyazaki Y, Mizumoto K, Dey G, Kudo T, Perrino J, Chen L, et al.
Nat Commun
. 2016 May;
7:11689.
PMID: 27229621
The accumulation of protein aggregates is a common pathological hallmark of many neurodegenerative diseases. However, we do not fully understand how aggregates are formed or the complex network of chaperones,...
9.
Miyazaki Y, Chen L, Chu B, Swigut T, Wandless T
Elife
. 2015 Aug;
4.
PMID: 26314864
Eukaryotic cells possess a variety of signaling pathways that prevent accumulation of unfolded and misfolded proteins. Chief among these is the heat shock response (HSR), which is assumed to respond...
10.
Collins S, Yang H, Bonger K, Guignet E, Wandless T, Meyer T
Mol Syst Biol
. 2015 Apr;
11(4):804.
PMID: 25908733
Numerous molecular components have been identified that regulate the directed migration of eukaryotic cells toward sources of chemoattractant. However, how the components of this system are wired together to coordinate...