Gerald R Crabtree
Overview
Explore the profile of Gerald R Crabtree including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
134
Citations
13106
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Sarott R, Gourisankar S, Karim B, Nettles S, Yang H, Dwyer B, et al.
Science
. 2024 Oct;
386(6717):eadl5361.
PMID: 39361741
Kinases are critical regulators of cellular function that are commonly implicated in the mechanisms underlying disease. Most drugs that target kinases are molecules that inhibit their catalytic activity, but here...
2.
Van Der Byl W, Nussing S, Peters T, Ahn A, Li H, Ledergor G, et al.
Immunity
. 2024 May;
57(6):1324-1344.e8.
PMID: 38776918
Peripheral CD8 T cell tolerance is a checkpoint in both autoimmune disease and anti-cancer immunity. Despite its importance, the relationship between tolerance-induced states and other CD8 T cell differentiation states...
3.
Gamble N, Bradu A, Caldwell J, McKeever J, Bolonduro O, Ermis E, et al.
Nat Immunol
. 2024 May;
25(6):1123.
PMID: 38755325
No abstract available.
4.
Gamble N, Bradu A, Caldwell J, McKeever J, Bolonduro O, Ermis E, et al.
Nat Immunol
. 2024 Apr;
25(5):860-872.
PMID: 38632339
Adaptive immunity relies on specialized effector functions elicited by lymphocytes, yet how antigen recognition activates appropriate effector responses through nonspecific signaling intermediates is unclear. Here we examined the role of...
5.
Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, et al.
Elife
. 2024 Mar;
12.
PMID: 38529532
Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in...
6.
Gourisankar S, Krokhotin A, Wenderski W, Crabtree G
Nat Rev Genet
. 2023 Nov;
25(5):340-361.
PMID: 38001317
Chromatin remodellers were once thought to be highly redundant and nonspecific in their actions. However, recent human genetic studies demonstrate remarkable biological specificity and dosage sensitivity of the thirty-two adenosine...
7.
Sarott R, Gourisankar S, Karim B, Nettles S, Yang H, Dwyer B, et al.
bioRxiv
. 2023 Nov;
PMID: 37961702
Protein kinases are disease drivers whose therapeutic targeting traditionally centers on inhibition of enzymatic activity. Here chemically induced proximity is leveraged to convert kinase inhibitors into context-specific activators of therapeutic...
8.
Gourisankar S, Krokhotin A, Ji W, Liu X, Chang C, Kim S, et al.
Nature
. 2023 Aug;
621(7977):E27.
PMID: 37596490
No abstract available.
9.
Gourisankar S, Krokhotin A, Ji W, Liu X, Chang C, Kim S, et al.
Nature
. 2023 Jul;
620(7973):417-425.
PMID: 37495688
Genes that drive the proliferation, survival, invasion and metastasis of malignant cells have been identified for many human cancers. Independent studies have identified cell death pathways that eliminate cells for...
10.
Hagihara H, Shoji H, Kuroiwa M, Graef I, Crabtree G, Nishi A, et al.
Mol Brain
. 2022 Nov;
15(1):94.
PMID: 36414974
Calcineurin (Cn), a phosphatase important for synaptic plasticity and neuronal development, has been implicated in the etiology and pathophysiology of neuropsychiatric disorders, including schizophrenia, intellectual disability, autism spectrum disorders, epilepsy,...