Thomas J Wandless
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Explore the profile of Thomas J Wandless including associated specialties, affiliations and a list of published articles.
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55
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3642
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Recent Articles
11.
Rakhit R, Navarro R, Wandless T
Chem Biol
. 2014 Sep;
21(9):1238-52.
PMID: 25237866
A common strategy to understand a biological system is to selectively perturb it and observe its response. Although technologies now exist to manipulate cellular systems at the genetic and transcript...
12.
Bonger K, Rakhit R, Payumo A, Chen J, Wandless T
ACS Chem Biol
. 2013 Nov;
9(1):111-5.
PMID: 24180414
Post-translational regulation of protein abundance in cells is a powerful tool for studying protein function. Here, we describe a novel genetically encoded protein domain that is degraded upon exposure to...
13.
Chu B, Kovary K, Guillaume J, Chen L, Teruel M, Wandless T
J Biol Chem
. 2013 Oct;
288(48):34575-87.
PMID: 24158444
To maintain protein homeostasis, cells must balance protein synthesis with protein degradation. Accumulation of misfolded or partially degraded proteins can lead to the formation of pathological protein aggregates. Here we...
14.
Sando 3rd R, Baumgaertel K, Pieraut S, Torabi-Rander N, Wandless T, Mayford M, et al.
Nat Methods
. 2013 Sep;
10(11):1085-8.
PMID: 24056874
Acute manipulation of gene and protein function in the brain is essential for understanding the mechanisms of nervous system development, plasticity and information processing. Here we describe a technique based...
15.
Cho U, Zimmerman S, Chen L, Owen E, Kim J, Kim S, et al.
PLoS One
. 2013 Aug;
8(8):e72393.
PMID: 23991108
Destabilizing domains are conditionally unstable protein domains that can be fused to a protein of interest resulting in degradation of the fusion protein in the absence of stabilizing ligand. These...
16.
Spiekerkoetter E, Tian X, Cai J, Hopper R, Sudheendra D, Li C, et al.
J Clin Invest
. 2013 Jul;
123(8):3600-13.
PMID: 23867624
Dysfunctional bone morphogenetic protein receptor-2 (BMPR2) signaling is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We used a transcriptional high-throughput luciferase reporter assay to screen 3,756 FDA-approved drugs...
17.
Alvarez J, Pan T, Ruth J, Feng Y, Zhou A, Pant D, et al.
Cancer Cell
. 2013 Jun;
24(1):30-44.
PMID: 23770012
Most deaths from breast cancer result from tumor recurrence, but mechanisms underlying tumor relapse are largely unknown. We now report that Par-4 is downregulated during tumor recurrence and that Par-4...
18.
Sellmyer M, Bronsart L, Imoto H, Contag C, Wandless T, Prescher J
Proc Natl Acad Sci U S A
. 2013 May;
110(21):8567-72.
PMID: 23650381
Interactions among neighboring cells underpin many physiological processes ranging from early development to immune responses. When these interactions do not function properly, numerous pathologies, including infection and cancer, can result....
19.
Watanabe K, Al-Bassam S, Miyazaki Y, Wandless T, Webster P, Arnold D
Cell Rep
. 2012 Dec;
2(6):1546-53.
PMID: 23246006
Trafficking of proteins specifically to the axonal or somatodendritic membrane allows neurons to establish and maintain polarized compartments with distinct morphology and function. Diverse evidence suggests that an actin-dependent vesicle...
20.
Sellmyer M, Chen L, Egeler E, Rakhit R, Wandless T
PLoS One
. 2012 Sep;
7(9):e43297.
PMID: 22984418
The ability to regulate protein levels in live cells is crucial to understanding protein function. In the interest of advancing the tool set for protein perturbation, we developed a protein...