Tashfeen Aslam
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Explore the profile of Tashfeen Aslam including associated specialties, affiliations and a list of published articles.
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7
Citations
82
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Recent Articles
1.
Akram A, Avlonitis N, Scholefield E, Vendrell M, McDonald N, Aslam T, et al.
Sci Rep
. 2019 Jun;
9(1):8422.
PMID: 31182770
Rapid in situ detection of pathogens coupled with high resolution imaging in the distal human lung has the potential to provide new insights and diagnostic utility in patients in whom...
2.
Akram A, Chankeshwara S, Scholefield E, Aslam T, McDonald N, Megia-Fernandez A, et al.
Sci Transl Med
. 2018 Oct;
10(464).
PMID: 30355797
Respiratory infections in mechanically ventilated patients caused by Gram-negative bacteria are a major cause of morbidity. Rapid and unequivocal determination of the presence, localization, and abundance of bacteria is critical...
3.
Aslam T, Miele A, Chankeshwara S, Megia-Fernandez A, Michels C, Akram A, et al.
Chem Sci
. 2018 Aug;
6(8):4946-4953.
PMID: 30155003
Aberrant fibrogenesis is a feature of many diseases in multiple organ systems. The lysyl oxidase family of enzymes are central to tissue homeostasis and elevated lysyl oxidase activity is implicated...
4.
Brunet A, Aslam T, Bradley M
Bioorg Med Chem Lett
. 2014 May;
24(14):3186-8.
PMID: 24856065
Diacetate protection of 5 and 6-carboxyfluorescein followed by synthesis of the N-hydroxysuccinimide esters allowed ready separation of the two isomers on a multi-gram scale. The 5 and 6-carboxyrhodamine B N-hydroxysuccinimide...
5.
Avlonitis N, Debunne M, Aslam T, McDonald N, Haslett C, Dhaliwal K, et al.
Org Biomol Chem
. 2013 May;
11(26):4414-8.
PMID: 23715090
Human neutrophil elastase (HNE) is a serine protease implicated in the pathogenesis of acute and chronic inflammatory disease. Here a series of, internally quenched, single fluorophore fluorescent reporters were synthesised...
6.
Keddie N, Ye Y, Aslam T, Luyten T, Bello D, Garnham C, et al.
Chem Commun (Camb)
. 2010 Oct;
47(1):242-4.
PMID: 20938532
The syntheses of four D-myo-inositol 1,4,5-trisphosphate (InsP(3)) derivatives, incorporating phosphate bioisosteres at the 5-position, are reported. The methyl phosphate ester and sulfate derivatives retain InsP(3) receptor (InsP(3)R) agonist activity; the...
7.
Bello D, Aslam T, Bultynck G, Slawin A, Roderick H, Bootman M, et al.
J Org Chem
. 2007 Jun;
72(15):5647-59.
PMID: 17585817
The design of a range of 4-position-modified D-myo-inositol 1,4,5-trisphosphate derivatives is described. The enantioselective synthesis of these compounds is reported, along with initial biological analysis, which indicates that these compounds...