Ahsan R Akram
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Explore the profile of Ahsan R Akram including associated specialties, affiliations and a list of published articles.
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54
Citations
862
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Recent Articles
1.
Koppensteiner L, Mathieson L, Neilson L, OConnor R, Akram A
FEBS Lett
. 2025 Jan;
599(5):713-723.
PMID: 39743376
Cancer-associated fibroblasts (CAFs) are the dominant nonmalignant component of the tumour microenvironment (TME). CAFs demonstrate a high level of inter- and intra-tumour heterogeneity in solid tumours, though the drivers of...
2.
Wang Q, Akram A, Dorward D, Talas S, Monks B, Thum C, et al.
Npj Imaging
. 2024 Jul;
2(1):17.
PMID: 38948152
Label-free autofluorescence lifetime is a unique feature of the inherent fluorescence signals emitted by natural fluorophores in biological samples. Fluorescence lifetime imaging microscopy (FLIM) can capture these signals enabling comprehensive...
3.
Mathieson L, Koppensteiner L, Dorward D, OConnor R, Akram A
Br J Cancer
. 2024 Apr;
130(11):1758-1769.
PMID: 38582812
Background: Cancer-associated fibroblasts (CAFs) are a dominant cell type in the stroma of non-small cell lung cancer (NSCLC). Fibroblast heterogeneity reflects subpopulations of CAFs, which can influence prognosis and treatment...
4.
Fernandes S, Williams E, Finlayson N, Stewart H, Dhaliwal C, Dorward D, et al.
Transl Lung Cancer Res
. 2024 Mar;
13(2):355-361.
PMID: 38496695
Lung cancer is the most common cause of cancer-related deaths worldwide. Early detection improves outcomes, however, existing sampling techniques are associated with suboptimal diagnostic yield and procedure-related complications. Autofluorescence-based fluorescence-lifetime...
5.
Adams A, Kufcsak A, Lochenie C, Khadem M, Akram A, Dhaliwal K, et al.
Biomed Opt Express
. 2024 Feb;
15(2):1132-1147.
PMID: 38404342
Fibre-optic based time-resolved fluorescence spectroscopy (TRFS) is an advanced spectroscopy technique that generates sample-specific spectral-temporal signature, characterising variations in fluorescence in real-time. As such, it can be used to interrogate...
6.
Hopkinson C, Matheson A, Finlayson N, Tanner M, Akram A, Henderson R
Biomed Opt Express
. 2024 Jan;
15(1):212-221.
PMID: 38223190
In this work a combined fluorescence lifetime and surface topographical imaging system is demonstrated. Based around a 126 × 192 time resolved single photon avalanche diode (SPAD) array operating in...
7.
Megia-Fernandez A, Marshall A, Akram A, Mills B, Chankeshwara S, Scholefield E, et al.
BME Front
. 2023 Oct;
2021(2021):9834163.
PMID: 37851586
There is a need to develop platforms delineating inflammatory biology of the distal human lung. We describe a platform technology approach to detect enzyme activity and observe drug inhibition in...
8.
Megia-Fernandez A, Marshall A, Akram A, Mills B, Chankeshwara S, Scholefield E, et al.
BME Front
. 2023 Oct;
4:0029.
PMID: 37849676
[This corrects the article DOI: 10.34133/2021/9834163.].
9.
Koppensteiner L, Mathieson L, Pattle S, Dorward D, OConnor R, Akram A
J Immunother Cancer
. 2023 Aug;
11(8).
PMID: 37648263
Purpose: An improved mechanistic understanding of immunosuppressive pathways in non-small cell lung cancer (NSCLC) is important to develop novel diagnostic and therapeutic approaches. Here, we investigate the prognostic significance of...
10.
OConnor R, Martinez B, Koppensteiner L, Mathieson L, Akram A
Front Immunol
. 2023 Jul;
14:1221532.
PMID: 37520560
Introduction: Tumour-reactive T cells producing the B-cell attractant chemokine CXCL13, in solid tumours, promote development of tertiary lymphoid structures (TLS) and are associated with improved prognosis and responsiveness to checkpoint...