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Tarjei S Mikkelsen

Explore the profile of Tarjei S Mikkelsen including associated specialties, affiliations and a list of published articles. Areas
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Articles 68
Citations 26936
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Recent Articles
1.
Salahudeen A, Choi S, Rustagi A, Zhu J, van Unen V, De la O S, et al.
Nature . 2020 Nov; 588(7839):670-675. PMID: 33238290
The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-dimensional in vitro human distal lung culture systems would strongly facilitate the investigation of pathologies such as interstitial...
2.
Salahudeen A, Choi S, Rustagi A, Zhu J, De la O S, Flynn R, et al.
bioRxiv . 2020 Aug; PMID: 32743583
The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange and is affected by disorders including interstitial lung disease, cancer, and SARS-CoV-2-associated COVID-19 pneumonia. Investigations of these localized...
3.
Replogle J, Norman T, Xu A, Hussmann J, Chen J, Cogan J, et al.
Nat Biotechnol . 2020 Apr; 38(8):954-961. PMID: 32231336
Single-cell CRISPR screens enable the exploration of mammalian gene function and genetic regulatory networks. However, use of this technology has been limited by reliance on indirect indexing of single-guide RNAs...
4.
Tsankov A, Wadsworth 2nd M, Akopian V, Charlton J, Allon S, Arczewska A, et al.
Development . 2019 Sep; 146(19). PMID: 31515224
Maintenance of pluripotency and specification towards a new cell fate are both dependent on precise interactions between extrinsic signals and transcriptional and epigenetic regulators. Directed methylation of cytosines by the...
5.
Cacchiarelli D, Qiu X, Srivatsan S, Manfredi A, Ziller M, Overbey E, et al.
Cell Syst . 2018 Sep; 7(3):258-268.e3. PMID: 30195438
Cellular reprogramming through manipulation of defined factors holds great promise for large-scale production of cell types needed for use in therapy and for revealing principles of gene regulation. However, most...
6.
Castaldi P, Guo F, Qiao D, Du F, Naing Z, Li Y, et al.
Am J Respir Crit Care Med . 2018 Aug; 199(1):52-61. PMID: 30079747
Rationale: The identification of causal variants responsible for disease associations from genome-wide association studies (GWASs) facilitates functional understanding of the biological mechanisms by which those genetic variants influence disease susceptibility....
7.
Tewhey R, Kotliar D, Park D, Liu B, Winnicki S, Reilly S, et al.
Cell . 2018 Feb; 172(5):1132-1134. PMID: 29474912
No abstract available.
8.
Kilens S, Meistermann D, Moreno D, Chariau C, Gaignerie A, Reignier A, et al.
Nat Commun . 2018 Jan; 9(1):360. PMID: 29367672
Induced pluripotent stem cells (iPSCs) have considerably impacted human developmental biology and regenerative medicine, notably because they circumvent the use of cells of embryonic origin and offer the potential to...
9.
Semrau S, Goldmann J, Soumillon M, Mikkelsen T, Jaenisch R, van Oudenaarden A
Nat Commun . 2017 Oct; 8(1):1096. PMID: 29061959
Gene expression heterogeneity in the pluripotent state of mouse embryonic stem cells (mESCs) has been increasingly well-characterized. In contrast, exit from pluripotency and lineage commitment have not been studied systematically...
10.
Kadoki M, Patil A, Thaiss C, Brooks D, Pandey S, Deep D, et al.
Cell . 2017 Sep; 171(2):398-413.e21. PMID: 28942919
A fundamental challenge in immunology is to decipher the principles governing immune responses at the whole-organism scale. Here, using a comparative infection model, we observe immune signal propagation within and...