Tarjei S Mikkelsen
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Explore the profile of Tarjei S Mikkelsen including associated specialties, affiliations and a list of published articles.
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68
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26936
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Recent Articles
11.
Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity
Yan K, Gevaert O, Zheng G, Anchang B, Probert C, Larkin K, et al.
Cell Stem Cell
. 2017 Jul;
21(1):78-90.e6.
PMID: 28686870
Several cell populations have been reported to possess intestinal stem cell (ISC) activity during homeostasis and injury-induced regeneration. Here, we explored inter-relationships between putative mouse ISC populations by comparative RNA-sequencing...
12.
Yan K, Janda C, Chang J, Zheng G, Larkin K, Luca V, et al.
Nature
. 2017 May;
545(7653):238-242.
PMID: 28467820
The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear translocation and...
13.
Pashos E, Park Y, Wang X, Raghavan A, Yang W, Abbey D, et al.
Cell Stem Cell
. 2017 Apr;
20(4):558-570.e10.
PMID: 28388432
Genome-wide association studies have struggled to identify functional genes and variants underlying complex phenotypes. We recruited a multi-ethnic cohort of healthy volunteers (n = 91) and used their tissue to...
14.
Grossman S, Zhang X, Wang L, Engreitz J, Melnikov A, Rogov P, et al.
Proc Natl Acad Sci U S A
. 2017 Feb;
114(7):E1291-E1300.
PMID: 28137873
Enhancers regulate gene expression through the binding of sequence-specific transcription factors (TFs) to cognate motifs. Various features influence TF binding and enhancer function-including the chromatin state of the genomic locus,...
15.
Woodruff L, Gorochowski T, Roehner N, Mikkelsen T, Densmore D, Gordon D, et al.
Nucleic Acids Res
. 2017 Jan;
45(3):1567-1568.
PMID: 28100691
No abstract available.
16.
Zheng G, Terry J, Belgrader P, Ryvkin P, Bent Z, Wilson R, et al.
Nat Commun
. 2017 Jan;
8:14049.
PMID: 28091601
Characterizing the transcriptome of individual cells is fundamental to understanding complex biological systems. We describe a droplet-based system that enables 3' mRNA counting of tens of thousands of single cells...
17.
Woodruff L, Gorochowski T, Roehner N, Mikkelsen T, Densmore D, Gordon D, et al.
Nucleic Acids Res
. 2016 Dec;
45(3):1553-1565.
PMID: 28007941
Genetic designs can consist of dozens of genes and hundreds of genetic parts. After evaluating a design, it is desirable to implement changes without the cost and burden of starting...
18.
Ernst J, Melnikov A, Zhang X, Wang L, Rogov P, Mikkelsen T, et al.
Nat Biotechnol
. 2016 Nov;
34(11):1180-1190.
PMID: 27701403
Massively parallel reporter assays (MPRAs) enable nucleotide-resolution dissection of transcriptional regulatory regions, such as enhancers, but only few regions at a time. Here we present a combined experimental and computational...
19.
Brenan L, Andreev A, Cohen O, Pantel S, Kamburov A, Cacchiarelli D, et al.
Cell Rep
. 2016 Oct;
17(4):1171-1183.
PMID: 27760319
Tumor-specific genomic information has the potential to guide therapeutic strategies and revolutionize patient treatment. Currently, this approach is limited by an abundance of disease-associated mutants whose biological functions and impacts...
20.
Ulirsch J, Nandakumar S, Wang L, Giani F, Zhang X, Rogov P, et al.
Cell
. 2016 Jun;
165(6):1530-1545.
PMID: 27259154
Genome-wide association studies (GWAS) have successfully identified thousands of associations between common genetic variants and human disease phenotypes, but the majority of these variants are non-coding, often requiring genetic fine-mapping,...