Manolis Kellis
Overview
Explore the profile of Manolis Kellis including associated specialties, affiliations and a list of published articles.
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Articles
309
Citations
58937
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Recent Articles
1.
Schreiber J, Boix C, Wook Lee J, Li H, Guan Y, Chang C, et al.
Genome Biol
. 2025 Feb;
26(1):31.
PMID: 39948633
No abstract available.
2.
Castanho I, Yeganeh P, Boix C, Morgan S, Mathys H, Prokopenko D, et al.
bioRxiv
. 2025 Jan;
PMID: 39868232
Background: A significant proportion of individuals maintain healthy cognitive function despite having extensive Alzheimer's disease (AD) pathology, known as cognitive resilience. Understanding the molecular mechanisms that protect these individuals can...
3.
Bonev B, Castelo-Branco G, Chen F, Codeluppi S, Corces M, Fan J, et al.
Nat Neurosci
. 2024 Dec;
28(1):216.
PMID: 39681663
No abstract available.
4.
Schmauch E, Ojanen J, Galani K, Jalkanen J, Harju K, Hollmen M, et al.
Nucleic Acids Res
. 2024 Dec;
53(1.
PMID: 39656909
Single-nuclei RNA sequencing remains a challenge for many human tissues, as incomplete removal of background signal masks cell-type-specific signals and interferes with downstream analyses. Here, we present Quality Clustering (QClus),...
5.
Blanchard J, Akay L, Davila-Velderrain J, von Maydell D, Mathys H, Davidson S, et al.
Nature
. 2024 Dec;
636(8043):E9.
PMID: 39633058
No abstract available.
6.
Bonev B, Castelo-Branco G, Chen F, Codeluppi S, Corces M, Fan J, et al.
Nat Neurosci
. 2024 Dec;
27(12):2292-2309.
PMID: 39627587
Over the past decade, single-cell genomics technologies have allowed scalable profiling of cell-type-specific features, which has substantially increased our ability to study cellular diversity and transcriptional programs in heterogeneous tissues....
7.
Mudge J, Carbonell-Sala S, Diekhans M, Martinez J, Hunt T, Jungreis I, et al.
Nucleic Acids Res
. 2024 Nov;
53(D1):D966-D975.
PMID: 39565199
GENCODE produces comprehensive reference gene annotation for human and mouse. Entering its twentieth year, the project remains highly active as new technologies and methodologies allow us to catalog the genome...
8.
Kaur G, Perteghella T, Carbonell-Sala S, Gonzalez-Martinez J, Hunt T, Madry T, et al.
bioRxiv
. 2024 Nov;
PMID: 39554180
Accurate and complete gene annotations are indispensable for understanding how genome sequences encode biological functions. For twenty years, the GENCODE consortium has developed reference annotations for the human and mouse...
9.
Stratified analysis identifies HIF-2 as a therapeutic target for highly immune-infiltrated melanomas
Huang A, Burke K, Porter R, Meiger L, Fatouros P, Yang J, et al.
bioRxiv
. 2024 Nov;
PMID: 39554029
While immune-checkpoint blockade (ICB) has revolutionized treatment of metastatic melanoma over the last decade, the identification of broadly applicable robust biomarkers has been challenging, driven in large part by the...
10.
Tanigawa Y, Kellis M
Am J Hum Genet
. 2024 Oct;
111(11):2478-2493.
PMID: 39442521
Balancing the tradeoff between quantity and quality of phenotypic data is critical in omics studies. Measurements below the limit of quantification (BLQ) are often tagged in quality control fields, but...