Alexandre Melnikov
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Explore the profile of Alexandre Melnikov including associated specialties, affiliations and a list of published articles.
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19
Citations
4455
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Recent Articles
1.
Donaldson G, Chou W, Manson A, Rogov P, Abeel T, Bochicchio J, et al.
Nat Microbiol
. 2020 Mar;
5(5):746-756.
PMID: 32152589
A complex microbiota inhabits various microenvironments of the gut, with some symbiotic bacteria having evolved traits to invade the epithelial mucus layer and reside deep within the intestinal tissue of...
2.
Weiss E, Lamers S, Henderson J, Melnikov A, Somasundaran M, Garber M, et al.
J Virol
. 2017 Nov;
92(2).
PMID: 29093087
Over 90% of the world's population is persistently infected with Epstein-Barr virus. While EBV does not cause disease in most individuals, it is the common cause of acute infectious mononucleosis...
3.
Cerqueira G, Cheeseman I, Schaffner S, Nair S, McDew-White M, Phyo A, et al.
Genome Biol
. 2017 Apr;
18(1):78.
PMID: 28454557
Background: Artemisinin-based combination therapies are the first line of treatment for Plasmodium falciparum infections worldwide, but artemisinin resistance has risen rapidly in Southeast Asia over the past decade. Mutations in...
4.
Grossman S, Zhang X, Wang L, Engreitz J, Melnikov A, Rogov P, et al.
Proc Natl Acad Sci U S A
. 2017 Feb;
114(7):E1291-E1300.
PMID: 28137873
Enhancers regulate gene expression through the binding of sequence-specific transcription factors (TFs) to cognate motifs. Various features influence TF binding and enhancer function-including the chromatin state of the genomic locus,...
5.
Ernst J, Melnikov A, Zhang X, Wang L, Rogov P, Mikkelsen T, et al.
Nat Biotechnol
. 2016 Nov;
34(11):1180-1190.
PMID: 27701403
Massively parallel reporter assays (MPRAs) enable nucleotide-resolution dissection of transcriptional regulatory regions, such as enhancers, but only few regions at a time. Here we present a combined experimental and computational...
6.
Hupalo D, Luo Z, Melnikov A, Sutton P, Rogov P, Escalante A, et al.
Nat Genet
. 2016 Jun;
48(8):953-8.
PMID: 27348298
Plasmodium vivax is a major public health burden, responsible for the majority of malaria infections outside Africa. We explored the impact of demographic history and selective pressures on the P....
7.
Ulirsch J, Nandakumar S, Wang L, Giani F, Zhang X, Rogov P, et al.
Cell
. 2016 Jun;
165(6):1530-1545.
PMID: 27259154
Genome-wide association studies (GWAS) have successfully identified thousands of associations between common genetic variants and human disease phenotypes, but the majority of these variants are non-coding, often requiring genetic fine-mapping,...
8.
Ma L, Chen Z, Huang D, Kutty G, Ishihara M, Wang H, et al.
Nat Commun
. 2016 Feb;
7:10740.
PMID: 26899007
Pneumocystis jirovecii is a major cause of life-threatening pneumonia in immunosuppressed patients including transplant recipients and those with HIV/AIDS, yet surprisingly little is known about the biology of this fungal...
9.
Sanborn A, Rao S, Huang S, Durand N, Huntley M, Jewett A, et al.
Proc Natl Acad Sci U S A
. 2015 Oct;
112(47):E6456-65.
PMID: 26499245
We recently used in situ Hi-C to create kilobase-resolution 3D maps of mammalian genomes. Here, we combine these maps with new Hi-C, microscopy, and genome-editing experiments to study the physical...
10.
Baniecki M, Faust A, Schaffner S, Park D, Galinsky K, Daniels R, et al.
PLoS Negl Trop Dis
. 2015 Mar;
9(3):e0003539.
PMID: 25781890
Plasmodium vivax, one of the five species of Plasmodium parasites that cause human malaria, is responsible for 25-40% of malaria cases worldwide. Malaria global elimination efforts will benefit from accurate...