T Michael Redmond
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Explore the profile of T Michael Redmond including associated specialties, affiliations and a list of published articles.
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81
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3888
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Recent Articles
1.
Ma W, Zhao L, Xu B, Fariss R, Redmond T, Zou J, et al.
Elife
. 2024 Nov;
12.
PMID: 39514271
Microglia exhibit both maladaptive and adaptive roles in the pathogenesis of neurodegenerative diseases and have emerged as a cellular target for central nervous system (CNS) disorders, including those affecting the...
2.
Damodar K, Dubois G, Guillou L, Mamaeva D, Pequignot M, Erkilic N, et al.
Mol Ther
. 2024 Oct;
32(12):4319-4336.
PMID: 39385467
Inherited retinal diseases (IRDs) are characterized by progressive vision loss. There are over 270 causative IRD genes, and variants within the same gene can cause clinically distinct disorders. One example...
3.
Riaz S, Sethna S, Duncan T, Naeem M, Redmond T, Riazuddin S, et al.
Mol Ther
. 2023 Oct;
31(12):3490-3501.
PMID: 37864333
Mutations in the PCDH15 gene, encoding protocadherin-15, are among the leading causes of Usher syndrome type 1 (USH1F), and account for up to 12% USH1 cases worldwide. A founder truncating...
4.
Uppal S, Postnikova O, Villasmil R, Rogozin I, Bocharov A, Eggerman T, et al.
Int J Mol Sci
. 2023 Jul;
24(14).
PMID: 37511618
Here, we present evidence that caveolae-mediated endocytosis using LDLR is the pathway for SARS-CoV-2 virus internalization in the ocular cell line ARPE-19. Firstly, we found that, while Angiotensin-converting enzyme 2...
5.
Uppal S, Poliakov E, Gentleman S, Redmond T
Adv Exp Med Biol
. 2023 Jul;
1415:533-537.
PMID: 37440083
The visual cycle is a complex biological process that involves the sequential action of proteins in the retinal pigment epithelial (RPE) cells and photoreceptors to modify and shuttle visual retinoids....
6.
William S, Duncan T, Redmond T
Sci Rep
. 2022 Dec;
12(1):22442.
PMID: 36575190
The ratio of saturated to monounsaturated fatty acids, thought to play a critical role in many cellular functions, is regulated by stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the biosynthesis...
7.
Uppal S, Liu T, Galvan E, Gomez F, Tittley T, Poliakov E, et al.
Life Sci Alliance
. 2022 Oct;
6(1).
PMID: 36265895
RPE65 retinol isomerase is an indispensable player in the visual cycle between the vertebrate retina and RPE. Although membrane association is critical for RPE65 function, its mechanism is not clear....
8.
Sethna S, Zein W, Riaz S, Giese A, Schultz J, Duncan T, et al.
Elife
. 2021 Nov;
10.
PMID: 34751129
Usher syndrome type I (USH1) is characterized by deafness, vestibular areflexia, and progressive retinal degeneration. The protein-truncating p.Arg245* founder variant of (USH1F) has an ~2% carrier frequency amongst Ashkenazi Jews...
9.
The Functional Consequences of the Novel Ribosomal Pausing Site in SARS-CoV-2 Spike Glycoprotein RNA
Postnikova O, Uppal S, Huang W, Kane M, Villasmil R, Rogozin I, et al.
Int J Mol Sci
. 2021 Jul;
22(12).
PMID: 34204305
The SARS-CoV-2 Spike glycoprotein (S protein) acquired a unique new 4 amino acid -PRRA- insertion sequence at amino acid residues (aa) 681-684 that forms a new furin cleavage site in...
10.
Sethna S, Scott P, Giese A, Duncan T, Jian X, Riazuddin S, et al.
Nat Commun
. 2021 Jun;
12(1):3906.
PMID: 34162842
Age-related macular degeneration (AMD) is a multifactorial neurodegenerative disorder. Although molecular mechanisms remain elusive, deficits in autophagy have been associated with AMD. Here we show that deficiency of calcium and...