Todd Duncan
Overview
Explore the profile of Todd Duncan including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
408
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Recent Articles
1.
Riaz S, Sethna S, Duncan T, Naeem M, Redmond T, Riazuddin S, et al.
Mol Ther
. 2023 Oct;
31(12):3490-3501.
PMID: 37864333
Mutations in the PCDH15 gene, encoding protocadherin-15, are among the leading causes of Usher syndrome type 1 (USH1F), and account for up to 12% USH1 cases worldwide. A founder truncating...
2.
William S, Duncan T, Redmond T
Sci Rep
. 2022 Dec;
12(1):22442.
PMID: 36575190
The ratio of saturated to monounsaturated fatty acids, thought to play a critical role in many cellular functions, is regulated by stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the biosynthesis...
3.
Sethna S, Zein W, Riaz S, Giese A, Schultz J, Duncan T, et al.
Elife
. 2021 Nov;
10.
PMID: 34751129
Usher syndrome type I (USH1) is characterized by deafness, vestibular areflexia, and progressive retinal degeneration. The protein-truncating p.Arg245* founder variant of (USH1F) has an ~2% carrier frequency amongst Ashkenazi Jews...
4.
Fan J, Rajapakse D, Peterson K, Lerner J, Parsa S, Ponduri A, et al.
Exp Eye Res
. 2021 Jul;
209:108698.
PMID: 34228964
Vision requires the transport and recycling of the pigment 11-cis retinaldehyde (retinal) between the retinal pigment epithelium (RPE) and photoreceptors. 11-cis retinal is also required for light-mediated photoreceptor death in...
5.
Sethna S, Scott P, Giese A, Duncan T, Jian X, Riazuddin S, et al.
Nat Commun
. 2021 Jun;
12(1):3906.
PMID: 34162842
Age-related macular degeneration (AMD) is a multifactorial neurodegenerative disorder. Although molecular mechanisms remain elusive, deficits in autophagy have been associated with AMD. Here we show that deficiency of calcium and...
6.
Li Y, Furhang R, Ray A, Duncan T, Soucy J, Mahdi R, et al.
Hum Mutat
. 2019 Jan;
40(4):426-443.
PMID: 30628748
Human RPE65 mutations cause a spectrum of retinal dystrophies that result in blindness. While RPE65 mutations have been almost invariably recessively inherited, a c.1430A>G (p.(D477G)) mutation has been reported to...
7.
Kutty R, Samuel W, Duncan T, Postnikova O, Jaworski C, Nagineni C, et al.
Cytokine
. 2017 Oct;
104:147-150.
PMID: 29054724
The inflammatory response may contribute to retinal pigment epithelial (RPE) dysfunction associated with the pathogenesis of age-related macular degeneration (AMD). We investigated whether the inflammatory response affects the expression of...
8.
Poliakov E, Samuel W, Duncan T, Gutierrez D, Mata N, Redmond T
PLoS One
. 2017 Apr;
12(4):e0176487.
PMID: 28448568
The therapeutic capacity of fenretinide (N-[4-hydroxyphenyl] retinamide; 4-HPR) has been demonstrated for several conditions, including cancer, obesity, diabetes, and ocular disease. Yet, the mechanisms of action for its pleiotropic effects...
9.
Samuel W, Jaworski C, Postnikova O, Kutty R, Duncan T, Tan L, et al.
Mol Vis
. 2017 Mar;
23:60-89.
PMID: 28356702
Purpose: The RPE cell line ARPE-19 provides a dependable and widely used alternative to native RPE. However, replication of the native RPE phenotype becomes more difficult because these cells lose...
10.
Kutty R, Samuel W, Boyce K, Cherukuri A, Duncan T, Jaworski C, et al.
Mol Vis
. 2016 Oct;
22:1156-1168.
PMID: 27733811
Purpose: Proinflammatory cytokines interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), and interleukin-1 beta (IL-1β) secreted by infiltrating lymphocytes or macrophages may play a role in triggering RPE dysfunction associated...