Steven S Carroll
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Explore the profile of Steven S Carroll including associated specialties, affiliations and a list of published articles.
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40
Citations
992
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Recent Articles
1.
Shurtleff V, Layton M, Parish C, Perkins J, Schreier J, Wang Y, et al.
J Med Chem
. 2024 Feb;
67(5):3935-3958.
PMID: 38365209
As SARS-CoV-2 continues to circulate, antiviral treatments are needed to complement vaccines. The virus's main protease, 3CLPro, is an attractive drug target in part because it recognizes a unique cleavage...
2.
Balibar C, Klein D, Zamlynny B, Diamond T, Fang Z, Cheney C, et al.
Sci Transl Med
. 2023 Feb;
15(684):eabn2038.
PMID: 36812345
Antiretroviral therapy inhibits HIV-1 replication but is not curative due to establishment of a persistent reservoir after virus integration into the host genome. Reservoir reduction is therefore an important HIV-1...
3.
Moore K, Schwaid A, Tudor M, Park S, Beshore D, Converso A, et al.
ACS Chem Biol
. 2022 Aug;
17(9):2595-2604.
PMID: 36044633
Although current antiretroviral therapy can control HIV-1 replication and prevent disease progression, it is not curative. Identifying mechanisms that can lead to eradication of persistent viral reservoirs in people living...
4.
Carroll S, Pearson D
Conserv Biol
. 2022 Jun;
14(6):1893-1897.
PMID: 35701948
Due to the structuring forces and large-scale physical processes that shape our biosphere, we often find that environmental and ecological data are either spatially or temporally-or both spatially and temporally-dependent....
5.
Bungard C, Williams P, Schulz J, Wiscount C, Holloway M, Loughran H, et al.
ACS Med Chem Lett
. 2017 Dec;
8(12):1292-1297.
PMID: 29259750
Using the HIV-1 protease binding mode of and as inspiration, a novel aspartate binding bicyclic piperazine sulfonamide core was designed and synthesized. The resulting HIV-1 protease inhibitor containing this core...
6.
Burlein C, Wang C, Xu M, Bhatt T, Stahlhut M, Ou Y, et al.
ACS Chem Biol
. 2017 Oct;
12(11):2858-2865.
PMID: 29024587
Allosteric integrase inhibitors (ALLINIs) bind to the lens epithelial-derived growth factor (LEDGF) pocket on HIV-1 integrase (IN) and possess potent antiviral effects. Rather than blocking proviral integration, ALLINIs trigger IN...
7.
Ma B, Luo B, Euler D, Cusick T, Wesolowski G, Glantschnig H, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2017 Feb;
390(4):435-441.
PMID: 28220210
The correlation of in vitro inhibition of cathepsin K (CatK) activity and in vivo suppression of collagen I biomarkers was examined with three selective CatK inhibitors to explore the potential...
8.
Su H, Rickert K, Burlein C, Narayan K, Bukhtiyarova M, Hurzy D, et al.
Proc Natl Acad Sci U S A
. 2017 Jan;
114(3):E297-E306.
PMID: 28039433
Current therapies for chronic pain can have insufficient efficacy and lead to side effects, necessitating research of novel targets against pain. Although originally identified as an oncogene, Tropomyosin-related kinase A...
9.
Rudd M, Butcher J, Nguyen K, McIntyre C, Romano J, Gilbert K, et al.
ChemMedChem
. 2015 Mar;
10(4):727-35.
PMID: 25759009
With the goal of identifying inhibitors of hepatitis C virus (HCV) NS3/4a protease that are potent against a wide range of genotypes and clinically relevant mutant viruses, several subseries of...
10.
Harper S, McCauley J, Rudd M, Ferrara M, DiFilippo M, Crescenzi B, et al.
ACS Med Chem Lett
. 2014 Jun;
3(4):332-6.
PMID: 24900473
A new class of HCV NS3/4a protease inhibitors containing a P2 to P4 macrocyclic constraint was designed using a molecular modeling-derived strategy. Building on the profile of previous clinical compounds...