Stephen J Smerdon
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Explore the profile of Stephen J Smerdon including associated specialties, affiliations and a list of published articles.
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55
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3206
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Recent Articles
1.
Torres Esteban M, Stewart M, Bragginton E, Meroni A, Pellizzari A, Jeanrenaud A, et al.
Life Sci Alliance
. 2025 Mar;
8(5).
PMID: 40049731
Ubiquitylation is critically implicated in the recognition and repair of DNA double-strand breaks. The adaptor protein MDC1 mediates the recruitment of the key DNA damage responsive E3 ubiquitin ligase RNF8...
2.
Westrip C, Smerdon S, Coleman M
Structure
. 2024 Sep;
32(11):2049-2062.e4.
PMID: 39276770
Eukaryotes have two paralogous developmentally regulated GTP-binding (DRG) proteins: DRG1 and DRG2, both of which have a conserved binding partner called DRG family regulatory protein 1 and 2 (DFRP1 and...
3.
Fletcher S, Hall C, Kennedy T, Pajusalu S, Wojcik M, Boora U, et al.
J Clin Invest
. 2023 Feb;
133(7.
PMID: 36795492
Although protein hydroxylation is a relatively poorly characterized posttranslational modification, it has received significant recent attention following seminal work uncovering its role in oxygen sensing and hypoxia biology. Although the...
4.
Fournier M, Rodrigue A, Milano L, Bleuyard J, Couturier A, Wall J, et al.
Elife
. 2022 Oct;
11.
PMID: 36269050
The tumour suppressor PALB2 stimulates RAD51-mediated homologous recombination (HR) repair of DNA damage, whilst its steady-state association with active genes protects these loci from replication stress. Here, we report that...
5.
Abu-Libdeh B, Jhujh S, Dhar S, Sommers J, Datta A, Longo G, et al.
J Clin Invest
. 2022 Jan;
132(5).
PMID: 35025765
Despite being the first homolog of the bacterial RecQ helicase to be identified in humans, the function of RECQL1 remains poorly characterized. Furthermore, unlike other members of the human RECQ...
6.
Pisco J, de Chiara C, Pacholarz K, Garza-Garcia A, Ogrodowicz R, Walker P, et al.
Nat Commun
. 2017 Aug;
8(1):203.
PMID: 28781362
ATP-phosphoribosyltransferase (ATP-PRT) is a hexameric enzyme in conformational equilibrium between an open and seemingly active state and a closed and presumably inhibited form. The structure-function relationship of allosteric regulation in...
7.
Kyrieleis O, McIntosh P, Webb S, Calder L, Lloyd J, Patel N, et al.
Cell Rep
. 2016 Dec;
17(12):3099-3106.
PMID: 28009280
BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair. It...
8.
Raz R, Burlina F, Ismail M, Downward J, Li J, Smerdon S, et al.
Angew Chem Int Ed Engl
. 2016 Sep;
55(42):13174-13179.
PMID: 27654901
We have developed a convenient method for the direct synthesis of peptide thioesters, versatile intermediates for peptide ligation and cyclic peptide synthesis. The technology uses a modified Boc SPPS strategy...
9.
Cherry A, Nott T, Kelly G, Rulten S, Caldecott K, Smerdon S
DNA Repair (Amst)
. 2015 Nov;
35:116-25.
PMID: 26519825
Aprataxin, aprataxin and PNKP-like factor (APLF) and polynucleotide kinase phosphatase (PNKP) are key DNA-repair proteins with diverse functions but which all contain a homologous forkhead-associated (FHA) domain. Their primary binding...
10.
Martino L, Pennell S, Kelly G, Busi B, Brown P, Atkinson R, et al.
Nucleic Acids Res
. 2014 Dec;
43(1):645-60.
PMID: 25488812
The La-related proteins (LARPs) form a diverse group of RNA-binding proteins characterized by the possession of a composite RNA binding unit, the La module. The La module comprises two domains,...