Simon Pennell
Overview
Explore the profile of Simon Pennell including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
404
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Recent Articles
1.
Tsai M, Caswell S, Morris E, Mann M, Pennell S, Kelly G, et al.
Retrovirology
. 2023 May;
20(1):5.
PMID: 37127613
Background: SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and it has been proposed that this is due...
2.
Arnold L, Groom H, Kunzelmann S, Schwefel D, Caswell S, Ordonez P, et al.
PLoS Pathog
. 2015 Oct;
11(10):e1005194.
PMID: 26431200
SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4+ T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase activity that reduces cellular dNTP to a level where reverse transcriptase cannot...
3.
Martino L, Pennell S, Kelly G, Busi B, Brown P, Atkinson R, et al.
Nucleic Acids Res
. 2014 Dec;
43(1):645-60.
PMID: 25488812
The La-related proteins (LARPs) form a diverse group of RNA-binding proteins characterized by the possession of a composite RNA binding unit, the La module. The La module comprises two domains,...
4.
Pennell S, Declais A, Li J, Haire L, Berg W, Saldanha J, et al.
Cell Rep
. 2014 Jul;
8(1):84-93.
PMID: 24981866
FAN1 is a structure-selective DNA repair nuclease with 5' flap endonuclease activity, involved in the repair of interstrand DNA crosslinks. It is the only eukaryotic protein with a virus-type replication-repair...
5.
Martino L, Pennell S, Kelly G, Bui T, Kotik-Kogan O, Smerdon S, et al.
Nucleic Acids Res
. 2011 Oct;
40(3):1381-94.
PMID: 22009680
Human La protein is an essential factor in the biology of both coding and non-coding RNAs. In the nucleus, La binds primarily to 3' oligoU containing RNAs, while in the...
6.
Pennell S, Westcott S, Ortiz-Lombardia M, Patel D, Li J, Nott T, et al.
Structure
. 2010 Dec;
18(12):1587-95.
PMID: 21134638
FHA domains are well established as phospho-dependent binding modules mediating signal transduction in Ser/Thr kinase signaling networks in both eukaryotic and prokaryotic species. Although they are unique in binding exclusively...
7.
8.
Brierley I, Gilbert R, Pennell S
Biochem Soc Trans
. 2008 Jul;
36(Pt 4):684-9.
PMID: 18631140
RNA pseudoknots are structural elements found in almost all classes of RNA. Pseudoknots form when a single-stranded region in the loop of a hairpin base-pairs with a stretch of complementary...
9.
Pennell S, Manktelow E, Flatt A, Kelly G, Smerdon S, Brierley I
RNA
. 2008 May;
14(7):1366-77.
PMID: 18495941
The stimulatory RNA of the Visna-Maedi virus (VMV) -1 ribosomal frameshifting signal has not previously been characterized but can be modeled either as a two-stem helix, reminiscent of the HIV-1...
10.
Brierley I, Pennell S, Gilbert R
Nat Rev Microbiol
. 2007 Jul;
5(8):598-610.
PMID: 17632571
RNA pseudoknots are structural elements found in almost all classes of RNA. First recognized in the genomes of plant viruses, they are now established as a widespread motif with diverse...