Stephen J Smerdon
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Explore the profile of Stephen J Smerdon including associated specialties, affiliations and a list of published articles.
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55
Citations
3206
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Recent Articles
11.
Larsen D, Hari F, Clapperton J, Gwerder M, Gutsche K, Altmeyer M, et al.
Nat Cell Biol
. 2014 Jul;
16(8):792-803.
PMID: 25064736
Chromosome breakage elicits transient silencing of ribosomal RNA synthesis, but the mechanisms involved remained elusive. Here we discover an in trans signalling mechanism that triggers pan-nuclear silencing of rRNA transcription...
12.
Pennell S, Declais A, Li J, Haire L, Berg W, Saldanha J, et al.
Cell Rep
. 2014 Jul;
8(1):84-93.
PMID: 24981866
FAN1 is a structure-selective DNA repair nuclease with 5' flap endonuclease activity, involved in the repair of interstrand DNA crosslinks. It is the only eukaryotic protein with a virus-type replication-repair...
13.
Ben-Addi A, Mambole-Dema A, Brender C, Martin S, Janzen J, Kjaer S, et al.
Proc Natl Acad Sci U S A
. 2014 Jun;
111(23):E2394-403.
PMID: 24912162
The MEK-1/2 kinase TPL-2 is critical for Toll-like receptor activation of the ERK-1/2 MAP kinase pathway during inflammatory responses, but it can transform cells following C-terminal truncation. IκB kinase (IKK)...
14.
Horejsi Z, Stach L, Flower T, Joshi D, Flynn H, Skehel J, et al.
Cell Rep
. 2014 Mar;
7(1):19-26.
PMID: 24656813
The R2TP cochaperone complex plays a critical role in the assembly of multisubunit machines, including small nucleolar ribonucleoproteins (snoRNPs), RNA polymerase II, and the mTORC1 and SMG1 kinase complexes, but...
15.
Smerdon S
Sci Signal
. 2014 Mar;
7(315):pe6.
PMID: 24595107
The phosphatidylinositol 3-kinase-like protein kinases (PIKKs) are large, atypical serine-threonine kinases that function in many important cellular signaling processes. Despite their prominence, and due to the complexity of their architecture...
16.
Spivey V, Whalan R, Hirst E, Smerdon S, Buxton R
FEMS Microbiol Lett
. 2013 Aug;
347(2):107-15.
PMID: 23915284
The ATP-binding cassette transporter Rv1747 is required for the growth of Mycobacterium tuberculosis in mice and in macrophages. Its structure suggests it is an exporter. Rv1747 forms a two-gene operon...
17.
Rock J, Lim D, Stach L, Ogrodowicz R, Keck J, Jones M, et al.
Science
. 2013 Apr;
340(6134):871-5.
PMID: 23579499
Scaffold-assisted signaling cascades guide cellular decision-making. In budding yeast, one such signal transduction pathway called the mitotic exit network (MEN) governs the transition from mitosis to the G1 phase of...
18.
Chapman T, Bouloc N, Buxton R, Chugh J, Lougheed K, Osborne S, et al.
Bioorg Med Chem Lett
. 2012 Apr;
22(9):3349-53.
PMID: 22469702
A high-throughput screen against PknB, an essential serine-threonine protein kinase present in Mycobacterium tuberculosis (M. tuberculosis), allowed the identification of an aminoquinazoline inhibitor which was used as a starting point...
19.
Yata K, Lloyd J, Maslen S, Bleuyard J, Skehel M, Smerdon S, et al.
Mol Cell
. 2012 Feb;
45(3):371-83.
PMID: 22325354
Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms...
20.
Jungmichel S, Clapperton J, Lloyd J, Hari F, Spycher C, Pavic L, et al.
Nucleic Acids Res
. 2012 Jan;
40(9):3913-28.
PMID: 22234878
Mdc1 is a large modular phosphoprotein scaffold that maintains signaling and repair complexes at double-stranded DNA break sites. Mdc1 is anchored to damaged chromatin through interaction of its C-terminal BRCT-repeat...