Stephane Sarrazin
Overview
Explore the profile of Stephane Sarrazin including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
16
Citations
977
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0
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Recent Articles
1.
Tillo M, Lamanna W, Dwyer C, Sandoval D, Pessentheiner A, Al-Azzam N, et al.
J Biol Chem
. 2022 Jun;
298(8):102159.
PMID: 35750212
Lysosomal storage diseases result in various developmental and physiological complications, including cachexia. To study the causes for the negative energy balance associated with cachexia, we assessed the impact of sulfamidase...
2.
Tong W, Dwyer C, Thacker B, Glass C, Brown J, Hamill K, et al.
Mol Ther
. 2017 Sep;
25(12):2743-2752.
PMID: 28958576
Iduronidase (IDUA)-deficient mice accumulate glycosaminoglycans in cells and tissues and exhibit many of the same neuropathological symptoms of patients suffering from Mucopolysaccharidosis I. Intravenous enzyme-replacement therapy for Mucopolysaccharidosis I ameliorates...
3.
Badillo A, Receveur-Brechot V, Sarrazin S, Cantrelle F, Delolme F, Fogeron M, et al.
Biochemistry
. 2017 May;
56(24):3029-3048.
PMID: 28535337
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a RNA-binding phosphoprotein composed of a N-terminal membrane anchor (AH), a structured domain 1 (D1), and two intrinsically disordered domains (D2...
4.
Lavie M, Sarrazin S, Montserret R, Descamps V, Baumert T, Duverlie G, et al.
J Virol
. 2014 Jul;
88(18):10584-97.
PMID: 24990994
Unlabelled: In spite of the high variability of its sequence, hepatitis C virus (HCV) envelope glycoprotein E2 contains several conserved regions. In this study, we explored the structural and functional...
5.
Saesen E, Sarrazin S, Laguri C, Sadir R, Maurin D, Thomas A, et al.
J Am Chem Soc
. 2013 Jun;
135(25):9384-90.
PMID: 23734709
The extensive functional repertoire of heparin and heparan sulfate, which relies on their ability to interact with a large number of proteins, has recently emerged. To understand the forces that...
6.
Lamanna W, Lawrence R, Sarrazin S, Lameda-Diaz C, Gordts P, Moremen K, et al.
J Biol Chem
. 2012 Sep;
287(43):36283-90.
PMID: 22952226
Inherited defects in the ability to catabolize glycosaminoglycans result in lysosomal storage disorders known as mucopolysaccharidoses (MPS), causing severe pathology, particularly in the brain. Enzyme replacement therapy has been used...
7.
Sarrazin S, Lamanna W, Esko J
Cold Spring Harb Perspect Biol
. 2011 Jun;
3(7).
PMID: 21690215
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged...
8.
Lamanna W, Lawrence R, Sarrazin S, Esko J
J Biol Chem
. 2011 Jan;
286(9):6955-62.
PMID: 21193389
Mucopolysaccharidoses are a group of genetically inherited disorders that result from the defective activity of lysosomal enzymes involved in glycosaminoglycan catabolism, causing their intralysosomal accumulation. Sanfilippo disease describes a subset...
9.
Gendrin C, Sarrazin S, Bonnaffe D, Jault J, Lortat-Jacob H, Dessen A
PLoS One
. 2010 Dec;
5(12):e15242.
PMID: 21179438
Yersinia pestis, the causative agent of bubonic plague, employs its type III secretion system to inject toxins into target cells, a crucial step in infection establishment. LcrV is an essential...
10.
Dix A, Fischer L, Sarrazin S, Redgate C, Esko J, Tor Y
Chembiochem
. 2010 Oct;
11(16):2302-10.
PMID: 20931643
Oligoarginine and guanidinium-rich molecular transporters have been shown to facilitate the intracellular delivery of a diverse range of biologically relevant cargos. Several such transporters have been suggested to interact with...