Hugues Lortat-Jacob
Overview
Explore the profile of Hugues Lortat-Jacob including associated specialties, affiliations and a list of published articles.
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111
Citations
2986
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Recent Articles
1.
Kemna J, Gout E, Daniau L, Lao J, Weissert K, Ammann S, et al.
Nat Immunol
. 2024 Apr;
25(5):929.
PMID: 38641723
No abstract available.
2.
Kemna J, Gout E, Daniau L, Lao J, Weissert K, Ammann S, et al.
Nat Immunol
. 2023 Feb;
24(3):558.
PMID: 36813983
No abstract available.
3.
Kemna J, Gout E, Daniau L, Lao J, Weissert K, Ammann S, et al.
Nat Immunol
. 2023 Feb;
24(3):414-422.
PMID: 36732425
Interferon-γ (IFNγ) is an important mediator of cellular immune responses, but high systemic levels of this cytokine are associated with immunopathology. IFNγ binds to its receptor (IFNγR) and to extracellular...
4.
Leisico F, Omeiri J, Le Narvor C, Beaudouin J, Hons M, Fenel D, et al.
Nat Commun
. 2022 Nov;
13(1):7110.
PMID: 36402845
Heparan sulfates are complex polysaccharides that mediate the interaction with a broad range of protein ligands at the cell surface. A key step in heparan sulfate biosynthesis is catalyzed by...
5.
El Masri R, Seffouh A, Roelants C, Seffouh I, Gout E, Perard J, et al.
Cell Rep
. 2022 Mar;
38(11):110516.
PMID: 35294879
Sulfs represent a class of unconventional sulfatases which provide an original post-synthetic regulatory mechanism for heparan sulfate polysaccharides and are involved in multiple physiopathological processes, including cancer. However, Sulfs remain...
6.
Laguri C, Sadir R, Gout E, Vives R, Lortat-Jacob H
Methods Mol Biol
. 2021 Oct;
2303:121-137.
PMID: 34626375
Heparan sulfate chains are complex and structurally diverse polysaccharides that interact with a large number of proteins, thereby regulating a vast array of biological functions. Understanding this activity requires obtaining...
7.
Genua M, Garcon L, Sergeeva Y, Saesen E, Musnier B, Buhot A, et al.
Anal Bioanal Chem
. 2021 Jul;
414(1):551-559.
PMID: 34258651
Differential sensing of proteins based on cross-reactive arrays and pattern recognition is a promising technique for the detection and identification of proteins. In this study, a rational biomimetic strategy has...
8.
Boulanger A, Thinat C, Zuchner S, Fradkin L, Lortat-Jacob H, Dura J
Nat Commun
. 2021 Mar;
12(1):1849.
PMID: 33758182
The remodeling of neurons is a conserved fundamental mechanism underlying nervous system maturation and function. Astrocytes can clear neuronal debris and they have an active role in neuronal remodeling. Developmental...
9.
Prechoux A, Simorre J, Lortat-Jacob H, Laguri C
Glycobiology
. 2021 Feb;
31(7):851-858.
PMID: 33554262
Heparan sulfates (HS) is a polysaccharide found at the cell surface, where it mediates interactions with hundreds of proteins and regulates major pathophysiological processes. HS is highly heterogeneous and structurally...
10.
Annaval T, Wild R, Cretinon Y, Sadir R, Vives R, Lortat-Jacob H
Molecules
. 2020 Sep;
25(18).
PMID: 32937952
Glycosylation is a common and widespread post-translational modification that affects a large majority of proteins. Of these, a small minority, about 20, are specifically modified by the addition of heparan...