Chrissa A Dwyer
Overview
Explore the profile of Chrissa A Dwyer including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
11
Citations
166
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Aguilar-Calvo P, Malik A, Sandoval D, Barback C, Orru C, Standke H, et al.
PLoS Pathog
. 2023 Sep;
19(9):e1011487.
PMID: 37747931
Select prion diseases are characterized by widespread cerebral plaque-like deposits of amyloid fibrils enriched in heparan sulfate (HS), a abundant extracellular matrix component. HS facilitates fibril formation in vitro, yet...
2.
Tillo M, Lamanna W, Dwyer C, Sandoval D, Pessentheiner A, Al-Azzam N, et al.
J Biol Chem
. 2022 Jun;
298(8):102159.
PMID: 35750212
Lysosomal storage diseases result in various developmental and physiological complications, including cachexia. To study the causes for the negative energy balance associated with cachexia, we assessed the impact of sulfamidase...
3.
Cook B, Archbold J, Nasr K, Girmay S, Goldstein S, Li P, et al.
Mol Imaging Biol
. 2022 Jun;
24(6):940-949.
PMID: 35655109
Purpose: The treatment of complex neurological diseases often requires the administration of large therapeutic drugs, such as antisense oligonucleotide (ASO), by lumbar puncture into the intrathecal space in order to...
4.
Bouwman L, den Hamer B, van den Heuvel A, Franken M, Jackson M, Dwyer C, et al.
Mol Ther Nucleic Acids
. 2021 Nov;
26:813-827.
PMID: 34729250
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most prevalent skeletal muscle dystrophies. Skeletal muscle pathology in individuals with FSHD is caused by inappropriate expression of the transcription factor DUX4,...
5.
Nagata T, Dwyer C, Yoshida-Tanaka K, Ihara K, Ohyagi M, Kaburagi H, et al.
Nat Biotechnol
. 2021 Aug;
39(12):1529-1536.
PMID: 34385691
Achieving regulation of endogenous gene expression in the central nervous system (CNS) with antisense oligonucleotides (ASOs) administered systemically would facilitate the development of ASO-based therapies for neurological diseases. We demonstrate...
6.
Nikan M, Tanowitz M, Dwyer C, Jackson M, Gaus H, Swayze E, et al.
J Med Chem
. 2020 Jul;
63(15):8471-8484.
PMID: 32677436
Despite recent advances, targeted delivery of therapeutic oligonucleotide to extra-hepatic tissues continues to be a challenging endeavor and efficient ligand-receptor systems need to be identified. To determine the feasibility of...
7.
Tong W, Dwyer C, Thacker B, Glass C, Brown J, Hamill K, et al.
Mol Ther
. 2017 Sep;
25(12):2743-2752.
PMID: 28958576
Iduronidase (IDUA)-deficient mice accumulate glycosaminoglycans in cells and tissues and exhibit many of the same neuropathological symptoms of patients suffering from Mucopolysaccharidosis I. Intravenous enzyme-replacement therapy for Mucopolysaccharidosis I ameliorates...
8.
Dwyer C, Scudder S, Lin Y, Dozier L, Phan D, Allen N, et al.
Sci Rep
. 2017 Apr;
7:46576.
PMID: 28418018
Sanfilippo syndrome, MPS IIIA-D, results from deficits in lysosomal enzymes that specifically degrade heparan sulfate, a sulfated glycosaminoglycan. The accumulation of heparan sulfate results in neurological symptoms, culminating in extensive...
9.
Dwyer C, Esko J
Mol Aspects Med
. 2016 Jul;
51:104-14.
PMID: 27418189
Idiopathic autism spectrum disorders (ASDs) are neurodevelopmental disorders with unknown etiology. An estimated 1:68 children in the U.S. are diagnosed with ASDs, making these disorders a substantial public health issue....
10.
Dwyer C, Katoh T, Tiemeyer M, Matthews R
J Biol Chem
. 2015 Mar;
290(16):10256-73.
PMID: 25737452
Protein O-mannosylation is a glycan modification that is required for normal nervous system development and function. Mutations in genes involved in protein O-mannosyl glycosylation give rise to a group of...