Philip L S M Gordts
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Explore the profile of Philip L S M Gordts including associated specialties, affiliations and a list of published articles.
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62
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2738
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Recent Articles
1.
Chen J, Esko J, Walker E, Gordts P, Baxter S, Toomey C
Ophthalmology
. 2025 Jan;
PMID: 39756691
Objective: Extracellular lipoprotein aggregation is a critical event in AMD pathogenesis. In this study, we sought to analyze associations between clinical and genetic-based factors related to lipoprotein metabolism and risk...
2.
Gengatharan J, Handzlik M, Chih Z, Ruchhoeft M, Secrest P, Ashley E, et al.
Cell Metab
. 2024 Nov;
37(1):274-290.e9.
PMID: 39547233
Dietary fat drives the pathogenesis of atherosclerotic cardiovascular disease (ASCVD), particularly through circulating cholesterol and triglyceride-rich lipoprotein remnants. Industrially produced trans-unsaturated fatty acids (TFAs) incorporated into food supplies significantly promote...
3.
Ramadoss S, Qin J, Tao B, Thomas N, Cao E, Wu R, et al.
Nat Cardiovasc Res
. 2024 Oct;
3(11):1356-1373.
PMID: 39455836
Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a type I transmembrane protein initially identified in nonmetastatic melanomas and has been associated with human heart failure; however, its role in cardiac...
4.
Painter C, Sankaranarayanan N, Nagarajan B, Clausen T, West A, Setiawan N, et al.
ACS Chem Biol
. 2024 Aug;
19(8):1820-1835.
PMID: 39099090
Neuropilin-1 acts as a coreceptor with vascular endothelial growth factor receptors to facilitate binding of its ligand, vascular endothelial growth factor. Neuropilin-1 also binds to heparan sulfate, but the functional...
5.
Yang X, Weber A, Mennillo E, Secrest P, Chang M, Wong S, et al.
Environ Health Perspect
. 2023 Sep;
131(9):97001.
PMID: 37668303
Background: Newborns can be exposed to inorganic arsenic (iAs) through contaminated drinking water, formula, and other infant foods. Epidemiological studies have demonstrated a positive association between urinary iAs levels and...
6.
DeForest N, Kavitha B, Hu S, Isaac R, Krohn L, Wang M, et al.
Cell Genom
. 2023 Jul;
3(7):100339.
PMID: 37492105
Loss-of-function mutations in hepatocyte nuclear factor 1A (HNF1A) are known to cause rare forms of diabetes and alter hepatic physiology through unclear mechanisms. In the general population, 1:100 individuals carry...
7.
Trieger G, Pessentheiner A, Purcell S, Green C, DeForest N, Willert K, et al.
J Biol Chem
. 2023 Mar;
299(5):104611.
PMID: 36931394
Adipose tissue plays a crucial role in maintaining metabolic homeostasis by storing lipids and glucose from circulation as intracellular fat. As peripheral tissues like adipose tissue become insulin resistant, decompensation...
8.
Ramms B, Pollow D, Zhu H, Nora C, Harrington A, Omar I, et al.
Diabetes
. 2022 Sep;
71(12):2513-2529.
PMID: 36162056
The transition from lean to obese states involves systemic metabolic remodeling that impacts insulin sensitivity, lipid partitioning, inflammation, and glycemic control. Here, we have taken a pharmacological approach to test...
9.
Tillo M, Lamanna W, Dwyer C, Sandoval D, Pessentheiner A, Al-Azzam N, et al.
J Biol Chem
. 2022 Jun;
298(8):102159.
PMID: 35750212
Lysosomal storage diseases result in various developmental and physiological complications, including cachexia. To study the causes for the negative energy balance associated with cachexia, we assessed the impact of sulfamidase...
10.
Porell R, Follmar J, Purcell S, Timm B, Laubach L, Kozirovskiy D, et al.
ACS Chem Biol
. 2022 May;
17(6):1534-1542.
PMID: 35574759
Glycosaminoglycans (GAGs) are a class of highly negatively charged membrane-associated and extracellular matrix polysaccharides involved in the regulation of myriad biological functions, including cell adhesion, migration, signaling, and differentiation, among...