Eleftherios Michailidis
Overview
Explore the profile of Eleftherios Michailidis including associated specialties, affiliations and a list of published articles.
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67
Citations
7868
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Recent Articles
1.
Jones C, Dangas G, Norris A, Koenig M, Li D, Shue T, et al.
Virology
. 2024 Oct;
600:110265.
PMID: 39427481
Primary human hepatocyte (PHH) models have limited longevity and require high inoculum for HBV infection with minimal spread. We aimed to develop 3D cell culture models to overcome the limitations...
2.
Li D, Donadu M, Shue T, Dangas G, Athanasiadis A, Lan S, et al.
Pharmaceuticals (Basel)
. 2024 Sep;
17(9).
PMID: 39338351
Human coronaviruses are a continuous threat to the human population and have limited antiviral treatments, and the recent COVID-19 pandemic sparked interest in finding new antiviral strategies, such as natural...
3.
Le Pen J, Paniccia G, Kinast V, Moncada-Velez M, Ashbrook A, Bauer M, et al.
PLoS Biol
. 2024 Sep;
22(9):e3002767.
PMID: 39316623
Interferons (IFNs) play a crucial role in the regulation and evolution of host-virus interactions. Here, we conducted a genome-wide arrayed CRISPR knockout screen in the presence and absence of IFN...
4.
Rialdi A, Duffy M, Scopton A, Fonseca F, Zhao J, Schwarz M, et al.
Nat Cancer
. 2023 Aug;
4(8):1157-1175.
PMID: 37537299
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. β-Catenin (CTNNB1)-mutated HCC represents 30% of cases of the disease with no precision therapeutics available. Using chemical libraries derived...
5.
Liu D, Ndongwe T, Ji J, Huber A, Michailidis E, Rice C, et al.
Viruses
. 2023 Apr;
15(4).
PMID: 37112961
Several direct-acting antivirals (DAAs) are available, providing interferon-free strategies for a hepatitis C cure. In contrast to DAAs, host-targeting agents (HTAs) interfere with host cellular factors that are essential in...
6.
Yu Y, Schneider W, Kass M, Michailidis E, Acevedo A, Pamplona Mosimann A, et al.
Sci Adv
. 2023 Apr;
9(15):eadg6265.
PMID: 37043562
Hepatitis B virus (HBV) chronically infects an estimated 300 million people, and standard treatments are rarely curative. Infection increases the risk of liver cirrhosis and hepatocellular carcinoma, and consequently, nearly...
7.
Lee D, Le Pen J, Yatim A, Dong B, Aquino Y, Ogishi M, et al.
Science
. 2022 Dec;
379(6632):eabo3627.
PMID: 36538032
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of , , or in five unrelated children with...
8.
Kabbani M, Michailidis E, Steensels S, Fulmer C, Luna J, Le Pen J, et al.
Cell Rep
. 2022 Sep;
40(11):111321.
PMID: 36103835
Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most strikingly an isoleucine to methionine substitution in patatin-like phospholipase domain-containing protein...
9.
Amblard F, Patel D, Michailidis E, Coats S, Kasthuri M, Biteau N, et al.
Eur J Med Chem
. 2022 Jul;
240:114554.
PMID: 35792384
More than 40 years into the pandemic, HIV remains a global burden and as of now, there is no cure in sight. Fortunately, highly active antiretroviral therapy (HAART) has been...
10.
Manry J, Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, et al.
Proc Natl Acad Sci U S A
. 2022 May;
119(21):e2200413119.
PMID: 35576468
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found...