Philip R Tedbury
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Explore the profile of Philip R Tedbury including associated specialties, affiliations and a list of published articles.
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47
Citations
970
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Recent Articles
1.
Disruption of LEDGF/p75-directed integration derepresses antisense transcription of the HIV-1 genome
Tedbury P, Mahboubi D, Puray-Chavez M, Shah R, Ukah O, Wahoski C, et al.
bioRxiv
. 2024 Dec;
PMID: 39677798
Disruption of HIV-1 Integrase (IN) interactions with the host-factor Lens Epithelium-Derived Growth Factor (LEDGF)/p75 leads to decreased, random integration, increased latent infection, and described here, accumulation of HIV-1 antisense RNA...
2.
Neilsen G, Mathew A, Castro J, McFadden W, Wen X, Ong Y, et al.
mBio
. 2024 Nov;
15(12):e0336823.
PMID: 39530689
The coronavirus-induced disease 19 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections, has had a devastating impact on millions of lives globally, with severe mortality rates and...
3.
McFadden W, Casey-Moore M, Bare G, Kirby K, Wen X, Li G, et al.
Cell Chem Biol
. 2024 Mar;
31(3):477-486.e7.
PMID: 38518746
Of the targets for HIV-1 therapeutics, the capsid core is a relatively unexploited but alluring drug target due to its indispensable roles throughout virus replication. Because of this, we aimed...
4.
Yapo V, Majumder K, Tedbury P, Wen X, Ong Y, Johnson M, et al.
J Virol
. 2023 Nov;
97(12):e0187022.
PMID: 37991365
Twenty-five years after the first report that HIV-2 infection can reduce HIV-1-associated pathogenesis in dual-infected patients, the mechanisms are still not well understood. We explored these mechanisms in cell culture...
5.
Cilento M, Wen X, Reeve A, Ukah O, A Snyder A, Carrillo C, et al.
Viruses
. 2023 Oct;
15(10).
PMID: 37896768
Tenofovir disoproxil fumarate (TDF) and islatravir (ISL, 4'-ethynyl-2-fluoro-2'-deoxyadensine, or MK-8591) are highly potent nucleoside reverse transcriptase inhibitors. Resistance to TDF and ISL is conferred by K65R and M184V, respectively. Furthermore,...
6.
Tedbury P, Manfredi C, Degenhardt F, Conway J, Horwath M, McCracken C, et al.
FASEB J
. 2023 Oct;
37(11):e23220.
PMID: 37801035
Patients with cystic fibrosis (CF) exhibit pronounced respiratory damage and were initially considered among those at highest risk for serious harm from SARS-CoV-2 infection. Numerous clinical studies have subsequently reported...
7.
Liu D, Ndongwe T, Ji J, Huber A, Michailidis E, Rice C, et al.
Viruses
. 2023 Apr;
15(4).
PMID: 37112961
Several direct-acting antivirals (DAAs) are available, providing interferon-free strategies for a hepatitis C cure. In contrast to DAAs, host-targeting agents (HTAs) interfere with host cellular factors that are essential in...
8.
Balasubramaniam A, Tedbury P, Mwangi S, Liu Y, Li G, Merlin D, et al.
Biomolecules
. 2023 Feb;
13(2).
PMID: 36830577
Background: Diarrhea is present in up to 30-50% of patients with COVID-19. The mechanism of SARS-CoV-2-induced diarrhea remains unclear. We hypothesized that enterocyte-enteric neuron interactions were important in SARS-CoV-2-induced diarrhea....
9.
Lan S, Neilsen G, Slack R, Cantara W, Castaner A, Lorson Z, et al.
bioRxiv
. 2023 Jan;
PMID: 36656782
The antiviral component of Paxlovid, nirmatrelvir (NIR), forms a covalent bond with Cys145 of SARS-CoV-2 nsp5. To explore NIR resistance we designed mutations to impair binding of NIR over substrate....
10.
Shah R, Gallardo C, Jung Y, Clock B, Dixon J, McFadden W, et al.
iScience
. 2022 Dec;
25(12):105490.
PMID: 36505924
It is unclear how the activation of HIV-1 transcription affects chromatin structure. We interrogated chromatin organization both genome-wide and nearby HIV-1 integration sites using Hi-C and ATAC-seq. In conjunction, we...