Andrew D Huber
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Explore the profile of Andrew D Huber including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
431
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Recent Articles
1.
Huber A, Jung Y, Li Y, Lin W, Wu J, Poudel S, et al.
J Med Chem
. 2024 Nov;
67(23):21631.
PMID: 39601372
No abstract available.
2.
Huber A, Jung Y, Li Y, Lin W, Wu J, Poudel S, et al.
J Med Chem
. 2024 Oct;
67(20):18549-18575.
PMID: 39405362
Pregnane X receptor (PXR) is a ligand-activated transcription factor that binds diverse compounds and upregulates drug metabolism machinery in response. PXR activation is detrimental to drug efficacy and safety because...
3.
Huber A, Lin W, Poudel S, Miller D, Chen T
Structure
. 2024 Oct;
32(12):2352-2363.e8.
PMID: 39389062
Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules containing a ligand for a protein of interest linked to an E3 ubiquitin ligase ligand that induce protein degradation through E3 recruitment to the...
4.
Huber A, Chen T
Elife
. 2024 Aug;
13.
PMID: 39158026
Complementary structural biology approaches reveal how an agonist and a covalent inhibitor simultaneously bind to a nuclear receptor.
5.
Garcia-Maldonado E, Huber A, Chai S, Nithianantham S, Li Y, Wu J, et al.
Nat Commun
. 2024 May;
15(1):4054.
PMID: 38744881
Nuclear receptors are ligand-activated transcription factors that can often be useful drug targets. Unfortunately, ligand promiscuity leads to two-thirds of receptors remaining clinically untargeted. PXR is a nuclear receptor that...
6.
Shao M, Pan Q, Tan H, Wu J, Lee H, Huber A, et al.
Genes Dis
. 2024 Apr;
11(4):101079.
PMID: 38560501
CYP3A5 is a cytochrome P450 (CYP) enzyme that metabolizes drugs and contributes to drug resistance in cancer. However, it remains unclear whether CYP3A5 directly influences cancer progression. In this report,...
7.
Gee R, Huber A, Chen T
Expert Opin Drug Metab Toxicol
. 2024 Jan;
20(1-2):9-23.
PMID: 38251638
Introduction: Pregnane X receptor (PXR) is a master xenobiotic sensor that transcriptionally controls drug metabolism and disposition pathways. PXR activation by pharmaceutical drugs, natural products, environmental toxins, etc. may decrease...
8.
Huber A, Poudel S, Wu J, Miller D, Lin W, Yang L, et al.
Nucleic Acids Res
. 2023 Dec;
52(4):1661-1676.
PMID: 38084912
Bromodomain and extraterminal (BET) proteins are extensively studied in multiple pathologies, including cancer. BET proteins modulate transcription of various genes, including those synonymous with cancer, such as MYC. Thus, BET...
9.
Gee R, Huber A, Wu J, Bajpai R, Loughran A, Pruett-Miller S, et al.
Acta Pharm Sin B
. 2023 Nov;
13(11):4523-4534.
PMID: 37969738
Pregnane X receptor (PXR) is a ligand-activated nuclear receptor that transcriptionally upregulates drug-metabolizing enzymes [.., cytochrome P450 3A4 (CYP3A4)] and transporters. Although the regulation of PXR target genes is well-characterized,...
10.
Huber A, Poudel S, Li Y, Lin W, Wu J, Miller D, et al.
Structure
. 2023 Sep;
31(12):1545-1555.e9.
PMID: 37729916
The human nuclear receptor (NR) family of transcription factors contains 48 proteins that bind lipophilic molecules. Approved NR therapies have had immense success treating various diseases, but lack of selectivity...