Somnath Dutta
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Explore the profile of Somnath Dutta including associated specialties, affiliations and a list of published articles.
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51
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1222
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Recent Articles
21.
Kumar A, P S, Gulati S, Dutta S
J Vis Exp
. 2021 Aug;
(173).
PMID: 34398142
In the past several years, technological and methodological advancements in single-particle cryo-electron microscopy (cryo-EM) have paved a new avenue for the high-resolution structure determination of biological macromolecules. Despite the remarkable...
22.
Malladi S, Patel U, Rajmani R, Singh R, Pandey S, Kumar S, et al.
ACS Infect Dis
. 2021 Jul;
7(8):2546-2564.
PMID: 34260218
The receptor binding domain (RBD) of SARS-CoV-2 is the primary target of neutralizing antibodies. We designed a trimeric, highly thermotolerant glycan engineered RBD by fusion to a heterologous, poorly immunogenic...
23.
Pramanick I, Sengupta N, Mishra S, Pandey S, Girish N, Das A, et al.
Structure
. 2021 May;
29(8):834-845.e5.
PMID: 33932324
Spike (S) glycoprotein of SARS-CoV2 exists chiefly in two conformations, open and closed. Most previous structural studies on S protein have been conducted at pH 8.0, but knowledge of the...
24.
Kumar A, Sengupta N, Dutta S
Nanomaterials (Basel)
. 2021 Apr;
11(3).
PMID: 33808009
In this manuscript, we report the application of graphene oxide (GO) in the preparation of cryo-electron microscopy (cryo-EM) and transmission electron microscopy (TEM) grids. We treated GO with water and...
25.
Malladi S, Schreiber D, Pramanick I, Sridevi M, Goldenzweig A, Dutta S, et al.
Curr Res Struct Biol
. 2021 Mar;
2:45-55.
PMID: 33688632
Stabilization of the metastable envelope glycoprotein (Env) of HIV-1 is hypothesized to improve induction of broadly neutralizing antibodies. We improved the expression yield and stability of the HIV-1 envelope glycoprotein...
26.
Malladi S, Singh R, Pandey S, Gayathri S, Kanjo K, Ahmed S, et al.
J Biol Chem
. 2020 Nov;
296:100025.
PMID: 33154165
Virtually all SARS-CoV-2 vaccines currently in clinical testing are stored in a refrigerated or frozen state prior to use. This is a major impediment to deployment in resource-poor settings. Furthermore,...
27.
Mondal A, Verma P, Sengupta N, Dutta S, Pandit S, Chattopadhyay K
Mol Microbiol
. 2020 Oct;
115(4):508-525.
PMID: 33089544
β-barrel pore-forming toxins perforate cell membranes by forming oligomeric β-barrel pores. The most crucial step is the membrane-insertion of the pore-forming motifs that create the transmembrane β-barrel scaffold. Molecular mechanism...
28.
Kundu N, Verma P, Kumar A, Dhar V, Dutta S, Chattopadhyay K
Biochemistry
. 2019 Dec;
59(4):605-614.
PMID: 31808340
Thermostable direct hemolysin (TDH) of is a membrane-damaging pore-forming toxin with potent cytolytic/cytotoxic activity. TDH exists as a tetramer consisting of protomers with a core β-sandwich domain, flanked by an...
29.
Ghosh E, Dwivedi H, Baidya M, Srivastava A, Kumari P, Stepniewski T, et al.
Cell Rep
. 2019 Sep;
28(13):3287-3299.e6.
PMID: 31553900
Desensitization, signaling, and trafficking of G-protein-coupled receptors (GPCRs) are critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of βarrs (βarr1 and 2) share a high degree of...
30.
Datta M, Aroli S, Karmakar K, Dutta S, Chakravortty D, Varshney U
Biochem Biophys Res Commun
. 2019 Aug;
518(1):38-43.
PMID: 31402116
Uracil is not always a mistakenly occurring base in DNA. Uracils in DNA genomes are known to be important in the life cycles of Bacillus subtilis phages (PBS1/2) and the...